CDC123抗体,Rabbit Polyclonal CDC123 Antibody
  • CDC123抗体,Rabbit Polyclonal CDC123 Antibody
  • CDC123抗体,Rabbit Polyclonal CDC123 Antibody
  • CDC123抗体,Rabbit Polyclonal CDC123 Antibody

CDC123抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-18
QQ交谈 微信洽谈

产品详情

中文名称:CDC123抗体英文名称:Rabbit Polyclonal CDC123 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3023 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: CDC123
2025-05-18 CDC123抗体 Rabbit Polyclonal CDC123 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3023 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesD123; C10orf7
WB Predicted band size39 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human CDC123
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: 293T and Hela cell lysates, Primary antibody: P06088(CDC123 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


           

参考文献

以下是关于CDC123抗体的模拟参考文献示例(注:部分内容为假设性概括,实际文献需通过学术数据库检索确认):

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1. **标题**:*CDC123 Antibody Characterization in Type 2 Diabetes Mellitus Studies*

**作者**:Bill, A. et al.

**摘要**:本研究利用兔源多克隆CDC123抗体,通过Western blot和免疫组化分析2型糖尿病患者外周血单核细胞中CDC123蛋白的表达水平,发现其表达异常与胰岛素抵抗相关,提示CDC123可能在糖代谢调控中发挥作用。

2. **标题**:*CDC123-CDK2 Interaction in Cancer Cell Cycle Regulation*

**作者**:Smith, J. et al.

**摘要**:通过免疫共沉淀(Co-IP)技术结合CDC123特异性抗体,揭示了CDC123蛋白与CDK2在癌细胞G1/S转换期的直接相互作用,为靶向细胞周期治疗提供了新靶点。

3. **标题**:*Development of a Monoclonal Antibody for CDC123 in Pancreatic Tissues*

**作者**:Johnson, R. et al.

**摘要**:报道了一种新型小鼠单克隆CDC123抗体的开发及验证,该抗体成功用于胰腺癌组织芯片的免疫荧光染色,表明CDC123高表达与患者预后不良相关。

4. **标题**:*CDC123 Antibody Application in Zebrafish Developmental Models*

**作者**:Lee, S. et al.

**摘要**:使用兔抗CDC123抗体研究斑马鱼胚胎发育中该蛋白的时空表达模式,发现其在早期神经管形成中显著上调,提示其在发育生物学中的潜在功能。

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建议通过**PubMed**或**Google Scholar**以“CDC123 antibody”或“CDC123 protein expression”为关键词检索真实文献,或结合具体研究领域(如糖尿病、癌症)进一步筛选。

       

背景信息

The CDC123 antibody targets the CDC123 protein, a conserved eukaryotic factor involved in cell cycle regulation and metabolic homeostasis. Initially identified through yeast genetic studies (as Cdc123p), human CDC123 is crucial for the assembly of the eukaryotic translation initiation factor 2 (eIF2), linking cell cycle progression to protein synthesis. It plays a role in G1/S transition and mitotic entry by regulating cyclin levels and coordinating nutrient availability with cell division.

CDC123 antibodies are typically monoclonal or polyclonal reagents developed in hosts like rabbits or mice, designed to detect endogenous CDC123 via techniques such as Western blotting, immunofluorescence, or immunohistochemistry. These tools have been instrumental in studying CDC123's expression patterns, which are upregulated in proliferating tissues and certain cancers, suggesting its potential as a biomarker for malignancy or therapeutic targeting.

Research using CDC123 antibodies has also explored its interaction with metabolic pathways, including mTOR signaling, and its implications in diseases beyond cancer, such as diabetes and neurodegenerative disorders. Commercial availability from suppliers like Abcam and Cell Signaling Technology has facilitated its use in both basic and translational research, though validation for specific applications (e.g., post-translational modifications) remains essential. Dysregulation of CDC123 is increasingly linked to pathologies involving disrupted proteostasis and cell cycle anomalies.

       
关键字: CDC123抗体;CDC123;CDC123 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
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