EME2抗体,Rabbit Polyclonal EME2 Antibody
  • EME2抗体,Rabbit Polyclonal EME2 Antibody
  • EME2抗体,Rabbit Polyclonal EME2 Antibody
  • EME2抗体,Rabbit Polyclonal EME2 Antibody

EME2抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-18
QQ交谈 微信洽谈

产品详情

中文名称:EME2抗体英文名称:Rabbit Polyclonal EME2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3120 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: EME2
2025-05-18 EME2抗体 Rabbit Polyclonal EME2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3120 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/30-1/150 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesSLX2B; gs125
WB Predicted band size41 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human EME2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: 231 cell lysate, Primary antibody: P06428(EME2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P06428(EME2 Antibody) at dilution 1/25. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P06428(EME2 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

参考文献

以下是3篇关于EME2抗体的模拟参考文献示例,基于相关研究领域背景虚构,供参考:

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### 1. **"EME2 Antibody Characterization in Meiotic DNA Repair"**

**作者**: Zhang L, et al.

**摘要**: 本研究通过制备兔源多克隆EME2抗体,验证了其在免疫印迹和免疫荧光中的特异性。研究发现EME2蛋白在减数分裂细胞中与结构特异性核酸酶复合体相互作用,参与双链断裂修复,其表达水平在生殖细胞中显著上调,提示其在基因组稳定性中的关键作用。

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### 2. **"EME2 Expression Profiling in Triple-Negative Breast Cancer Using a Novel Monoclonal Antibody"**

**作者**: Gupta R, et al.

**摘要**: 团队开发了一种高特异性小鼠单克隆EME2抗体,用于分析三阴性乳腺癌组织中的蛋白表达。结果显示,EME2在肿瘤组织中过表达,且与化疗耐药性相关,表明其可能作为潜在治疗靶点或预后标志物。

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### 3. **"Structural Insights into EME2-MUS81 Complex via Cryo-EM with Affinity-Purified Antibodies"**

**作者**: Sato K, et al.

**摘要**: 利用亲和纯化的EME2抗体,研究通过冷冻电镜解析了EME2与MUS81核酸酶复合体的三维结构,揭示了其参与DNA交联修复的分子机制。抗体在复合体分离和功能抑制实验中表现出高效特异性,为靶向治疗提供了结构基础。

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**注**:以上文献为模拟示例,实际引用需查询真实数据库(如PubMed、Web of Science)并核实来源。

       

背景信息

EME2 (Essential Meiotic Structure-Specific Endonuclease subunit 2) is a protein involved in DNA repair and recombination processes, particularly in resolving Holliday junctions and other DNA secondary structures during meiosis and mitosis. It functions as a regulatory subunit within multi-protein nuclease complexes, such as the SLX1-SLX4 or XPF-ERCC1 complexes, which are critical for maintaining genomic stability. EME2 stabilizes and modulates the enzymatic activity of its catalytic partners, enabling precise cleavage of DNA repair intermediates. Dysregulation of EME2 has been implicated in genomic instability disorders and cancer progression.

Antibodies targeting EME2 are primarily used in research to investigate its role in DNA repair mechanisms, cellular responses to replication stress, and cancer biology. These antibodies enable the detection of EME2 expression levels, subcellular localization, and interaction partners through techniques like Western blotting, immunofluorescence, and co-immunoprecipitation. Studies using EME2-specific antibodies have revealed its overexpression in certain cancers, where it may contribute to chemoresistance by enhancing DNA repair efficiency in tumor cells. Conversely, reduced EME2 expression has been linked to increased sensitivity to DNA-damaging therapies. The development and validation of EME2 antibodies thus support both basic research on genome maintenance pathways and translational studies exploring biomarkers or therapeutic targets in oncology.

       
关键字: EME2抗体;EME2;EME2 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
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