GPR180抗体,Rabbit Polyclonal GPR180 Antibody
  • GPR180抗体,Rabbit Polyclonal GPR180 Antibody
  • GPR180抗体,Rabbit Polyclonal GPR180 Antibody
  • GPR180抗体,Rabbit Polyclonal GPR180 Antibody

GPR180抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-18
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产品详情

中文名称:GPR180抗体英文名称:Rabbit Polyclonal GPR180 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3197 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: GPR180
2025-05-18 GPR180抗体 Rabbit Polyclonal GPR180 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3197 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/20-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesITR
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human GPR180
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P06640(GPR180 Antibody) at dilution 1/35. (Original magnification: ×200)    


           

参考文献

以下是基于GPR180相关研究领域生成的模拟参考文献示例(非真实文献,仅供格式参考):

1. **文献名称**:*GPR180 Antibody Characterization and Its Role in Vascular Smooth Muscle Cell Migration*

**作者**:Smith A, et al.

**摘要**:本研究验证了GPR180抗体的特异性,并发现GPR180通过调节细胞内钙信号通路影响血管平滑肌细胞迁移,提示其在动脉粥样硬化中的潜在作用。

2. **文献名称**:*Expression Profiling of GPR180 in Tumor Stroma Using a Novel Monoclonal Antibody*

**作者**:Chen L, et al.

**摘要**:开发了一种高特异性抗GPR180单克隆抗体,证实GPR180在肿瘤基质细胞中高表达,可能与肿瘤微环境中的血管生成相关。

3. **文献名称**:*GPR180 Antibody-Based Detection of Receptor Localization in Cardiac Fibroblasts*

**作者**:Yamamoto K, et al.

**摘要**:通过免疫荧光和Western blot分析,揭示了GPR180在心脏成纤维细胞膜上的定位,并发现其敲减可抑制纤维化相关基因表达。

4. **文献名称**:*GPR180 Interaction with β-Arrestin: Insights from Antibody-Mediated Blockade Experiments*

**作者**:Patel R, et al.

**摘要**:利用GPR180功能阻断抗体,证明其与β-arrestin的相互作用对GPCR内吞及下游MAPK信号通路激活至关重要。

**说明**:以上内容为领域知识模拟生成,实际文献需通过PubMed/Google Scholar等平台检索关键词“GPR180 antibody”“GPR180 function”获取。建议结合具体研究方向筛选文献(如肿瘤、心血管或信号机制)。

       

背景信息

GPR180. also known as G-protein coupled receptor 180. is a member of the adhesion class of G-protein coupled receptors (GPCRs), a large family of cell surface proteins involved in signal transduction. Initially identified through genomic studies, GPR180 remains an understudied orphan receptor, meaning its endogenous ligand and precise physiological roles are not fully elucidated. It is characterized by a long extracellular N-terminal domain, a feature common to adhesion GPCRs, which may mediate cell-cell or cell-matrix interactions. Emerging research suggests GPR180 is expressed in various tissues, including the vascular system, lungs, and kidneys, with potential roles in angiogenesis, tissue remodeling, and metabolic regulation. Its involvement in diseases such as cancer, fibrosis, and cardiovascular disorders has been hypothesized but requires further validation.

GPR180 antibodies are essential tools for investigating the receptor's expression, localization, and function. These antibodies are typically developed against specific epitopes in the extracellular or intracellular domains of GPR180 and are validated for applications like Western blotting, immunohistochemistry, and flow cytometry. Due to the receptor's orphan status and low expression levels in many tissues, antibody specificity is critical to avoid cross-reactivity with other GPCRs. Recent studies using GPR180 antibodies have linked the receptor to signaling pathways involving cAMP and MAPK, suggesting its potential interplay with cellular proliferation and migration. However, the functional relevance of GPR180 in health and disease remains an active area of research, necessitating reliable antibody reagents for mechanistic exploration.

       
关键字: GPR180抗体;GPR180;GPR180 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
询盘

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