IRX5抗体,Rabbit Polyclonal IRX5 Antibody
  • IRX5抗体,Rabbit Polyclonal IRX5 Antibody
  • IRX5抗体,Rabbit Polyclonal IRX5 Antibody
  • IRX5抗体,Rabbit Polyclonal IRX5 Antibody

IRX5抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-18
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产品详情

中文名称:IRX5抗体英文名称:Rabbit Polyclonal IRX5 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 3253 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: IRX5
2025-05-18 IRX5抗体 Rabbit Polyclonal IRX5 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 3253 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/30-1/150 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesHMMS; IRXB2; IRX-2a
WB Predicted band size50 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human IRX5
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse lung tissue lysate, Primary antibody: P06764(IRX5 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 4 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P06764(IRX5 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P06764(IRX5 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于IRX5抗体的参考文献示例(均为虚构,仅用于示例用途):

1. **文献名称**:*IRX5 regulates ventricular action potential duration through transcriptional control of potassium channels*

**作者**:Smith J. et al. (2015)

**摘要**:本研究通过免疫组化和小鼠模型,利用IRX5抗体揭示了IRX5在心室肌细胞中的梯度表达模式,发现其通过调控Kv4.2等钾离子通道基因影响心脏电生理特性。

2. **文献名称**:*IRX5 promotes glioma progression by activating the Wnt/β-catenin pathway*

**作者**:Zhang L. et al. (2018)

**摘要**:通过Western blot和免疫荧光实验,结合IRX5抗体,研究者证实IRX5在胶质瘤中高表达,并通过激活Wnt通路促进肿瘤侵袭和干细胞特性。

3. **文献名称**:*Developmental role of IRX5 in limb patterning and skeletal formation*

**作者**:Lee S. et al. (2012)

**摘要**:利用IRX5抗体进行胚胎组织染色,发现IRX5在小鼠肢体发育中调控骨骼形成相关基因(如Sox9),揭示了其在前-后轴模式决定中的关键作用。

4. **文献名称**:*Chromatin profiling identifies IRX5 as a novel oncogenic driver in breast cancer*

**作者**:Gupta R. et al. (2020)

**摘要**:通过ChIP-seq结合IRX5抗体,研究者发现IRX5在乳腺癌中与染色质重塑复合物结合,促进促癌基因(如MYC)的转录,提示其作为潜在治疗靶点。

(注:以上文献及作者为虚构示例,如需真实文献建议通过PubMed/Google Scholar检索IRX5及相关关键词。)

       

背景信息

The IRX5 antibody is a research tool designed to detect and study the Iroquois homeobox protein 5 (IRX5), a transcription factor belonging to the Iroquois (Irx) gene family. This family, conserved across vertebrates, plays critical roles in embryonic development, particularly in patterning neural, cardiac, and limb tissues. IRX5 is involved in regulating gene expression networks during organogenesis, with notable functions in heart development, where it influences chamber-specific differentiation, and in the nervous system, where it contributes to neuronal subtype specification. Dysregulation of IRX5 has been linked to congenital defects, including cardiac abnormalities, and its aberrant expression is implicated in cancers such as melanoma and colorectal carcinoma, where it may act as an oncogene or tumor suppressor depending on context.

The IRX5 antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to visualize protein localization, expression levels, and interactions in cellular or tissue samples. Its validation typically includes testing for specificity via knockout controls or siRNA knockdown. Researchers employ this antibody to explore IRX5's role in developmental biology, disease mechanisms, and potential therapeutic targets. As Irx proteins often exhibit functional redundancy, precise detection of IRX5 is crucial for disentangling its unique contributions within complex regulatory pathways. Commercial availability from multiple biotech vendors has facilitated its adoption in both basic and translational research settings.

       
关键字: IRX5抗体;IRX5;IRX5 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
询盘

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