The JDP2 (Jun Dimerization Protein 2) antibody is a tool used to detect and study the JDP2 protein, a member of the basic region-leucine zipper (bZIP) family of transcription regulators. JDP2. encoded by the *JDP2* gene, functions as a transcriptional repressor or co-regulator by interacting with AP-1 complexes (e.g., Jun/Fos proteins) and other transcription factors through its bZIP domain. It plays roles in cellular processes such as cell cycle progression, apoptosis, and stress response, and is implicated in pathologies including cancer, fibrosis, and inflammatory diseases.
JDP2 antibodies are widely utilized in research to investigate its expression patterns, subcellular localization, and molecular interactions. These antibodies are essential for techniques like Western blotting, immunohistochemistry, and chromatin immunoprecipitation (ChIP). Researchers often validate antibody specificity using knockout cell lines or siRNA-mediated JDP2 depletion to ensure accurate detection. Commercially available JDP2 antibodies vary in host species (e.g., rabbit, mouse), clonality (monoclonal/polyclonal), and epitope targets, which may influence experimental outcomes.
Recent studies highlight JDP2's dual role in gene regulation—repressing AP-1 target genes while facilitating chromatin remodeling through histone chaperone activity. Its involvement in diseases like hepatocellular carcinoma and pulmonary fibrosis underscores the antibody's relevance in both mechanistic and translational research. Proper antibody selection and validation remain critical for elucidating JDP2's context-dependent functions.