HMGCL抗体,Rabbit Polyclonal HMGCL Antibody
  • HMGCL抗体,Rabbit Polyclonal HMGCL Antibody
  • HMGCL抗体,Rabbit Polyclonal HMGCL Antibody
  • HMGCL抗体,Rabbit Polyclonal HMGCL Antibody

HMGCL抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-19
QQ交谈 微信洽谈

产品详情

中文名称:HMGCL抗体英文名称:Rabbit Polyclonal HMGCL Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 4109 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: HMGCL
2025-05-19 HMGCL抗体 Rabbit Polyclonal HMGCL Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 4109 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesHL
WB Predicted band size34 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human HMGCL
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Mouse brain tissue, Mouse fetal tissue, Mouse adrenal gland tissue lysates, Primary antibody: P08401(HMGCL Antibody) at dilution 1/1200, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 second    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08401(HMGCL Antibody) at dilution 1/75. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P08401(HMGCL Antibody) at dilution 1/75. (Original magnification: ×200)    


           

参考文献

以下是关于HMGCL抗体的3篇参考文献,包含文献名称、作者及摘要概述:

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1. **"Autoantibodies against HMGCL in patients with autoimmune hepatitis: Clinical and genetic associations"**

*Authors: Tanaka A., et al. (2020)*

**摘要**:本研究在自身免疫性肝炎(AIH)患者中发现新型抗HMGCL抗体,并探讨其与疾病活动性和HLA基因型的关联。抗体阳性患者表现出更严重的肝功能异常,提示其可能作为AIH的生物标志物。

2. **"Anti-HMG-CoA Lyase Antibodies in Metabolic Myopathies: Diagnostic Utility"**

*Authors: Smith J., et al. (2018)*

**摘要**:通过ELISA检测HMGCL抗体在代谢性肌病患者的血清中的表达,发现抗体水平与HMGCL酶活性缺失相关,提出其可作为HMGCL缺乏症的辅助诊断工具,尤其适用于婴幼儿遗传筛查。

3. **"HMGCL Antibody as a Novel Biomarker in Idiopathic Inflammatory Myopathies"**

*Authors: Chen L., et al. (2021)*

**摘要**:首次报道特发性炎症性肌病(IIM)患者中存在抗HMGCL抗体,抗体阳性与肌肉病理损伤程度相关,提示其在IIM亚型分型及靶向治疗中的潜在应用价值。

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**注**:以上文献信息为示例,实际引用时需核实具体来源及原文内容。建议通过PubMed或专业数据库(如Web of Science)检索最新研究。若需实验用HMGCL抗体的文献,可补充方向说明。

       

背景信息

**Background of HMGCL Antibodies**

HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase) is a mitochondrial enzyme critical in ketogenesis and leucine metabolism, catalyzing the cleavage of HMG-CoA to acetoacetate and acetyl-CoA. Deficiencies in HMGCL activity due to genetic mutations cause a rare autosomal recessive disorder, HMGCL deficiency, characterized by metabolic crises, hypoketotic hypoglycemia, and organic acidemia. Antibodies targeting HMGCL are essential tools for diagnosing this condition, enabling detection of enzyme expression levels in clinical samples.

Beyond metabolic disorders, HMGCL has gained attention in cancer research. Studies suggest its role in tumor metabolism, particularly in cancers reliant on ketone body utilization or the mevalonate pathway. HMGCL antibodies are employed in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess its expression and subcellular localization in tumor tissues. These studies help explore HMGCL's potential as a therapeutic target or biomarker in oncology.

Commercially available HMGCL antibodies are typically raised against specific epitopes of human HMGCL, with cross-reactivity tested in common model organisms. Their applications extend to elucidating HMGCL's interaction networks, post-translational modifications, and tissue-specific expression patterns. Recent research also investigates HMGCL's involvement in signaling pathways linking metabolism to cell proliferation and survival, highlighting its broader physiological and pathological relevance.

       
关键字: HMGCL抗体;HMGCL;HMGCL Antibody;

公司简介

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  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
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