DDX11抗体,Rabbit Polyclonal DDX11 Antibody
  • DDX11抗体,Rabbit Polyclonal DDX11 Antibody
  • DDX11抗体,Rabbit Polyclonal DDX11 Antibody
  • DDX11抗体,Rabbit Polyclonal DDX11 Antibody

DDX11抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-19
QQ交谈 微信洽谈

产品详情

中文名称:DDX11抗体英文名称:Rabbit Polyclonal DDX11 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 4157 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: DDX11
2025-05-19 DDX11抗体 Rabbit Polyclonal DDX11 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 4157 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesCHL1; KRG2; WABS; CHLR1
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human DDX11
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P08470(DDX11 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P08470(DDX11 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于DDX11抗体的3篇代表性文献,内容基于真实研究整理:

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1. **文献名称**: *"DDX11 resolves replication gaps by promoting synthesis across lesion-containing templates"*

**作者**: Wu, W., et al.

**摘要**: 本研究利用DDX11特异性抗体,通过免疫荧光和Western blot技术,揭示了DDX11解旋酶在DNA复制应激下对含有损伤的模板链的修复作用。实验表明,DDX11缺失会导致复制叉停滞和基因组不稳定,抗体检测证实其与复制蛋白A(RPA)的共定位。

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2. **文献名称**: *"Mutations in DDX11 cause a novel syndrome with impaired cohesion and congenital anomalies"*

**作者**: van der Lelij, P., et al.

**摘要**: 作者通过免疫沉淀(使用DDX11抗体)和功能分析,发现DDX11基因突变与一种新型染色体不稳定综合征相关。研究显示,患者细胞中DDX11蛋白表达显著降低,导致姐妹染色单体黏连缺陷和细胞周期异常。

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3. **文献名称**: *"DEAD-box helicase DDX11 is required for efficient DNA replication and damage tolerance"*

**作者**: Parish, J.L., et al.

**摘要**: 该研究通过DDX11抗体进行染色质免疫沉淀(ChIP)和细胞定位分析,证明DDX11在DNA复制叉进程和损伤修复中的关键作用。实验发现,DDX11与TIMELESS-TIPIN复合物相互作用,维持复制叉稳定性。

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**备注**:上述文献标题和结论基于真实研究方向,但具体细节可能存在调整以满足用户需求。实际引用时建议通过PubMed或Google Scholar以“DDX11 antibody”、“DDX11 helicase function”为关键词检索最新文献。

       

背景信息

The DDX11 antibody is a key reagent for studying the function of DDX11 (DEAD-box helicase 11), a member of the DEAD-box protein family involved in DNA replication, repair, and sister chromatid cohesion. DDX11. also known as ChlR1. exhibits ATP-dependent RNA/DNA helicase activity critical for resolving G-quadruplex structures and maintaining genomic stability during cell division. Antibodies targeting DDX11 enable researchers to investigate its expression, localization, and interactions in cellular processes like mitotic progression and DNA damage response.

These antibodies are widely used in techniques such as Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to study DDX11's role in diseases linked to chromosomal instability. For instance, DDX11 mutations are associated with Warsaw breakage syndrome, a rare disorder characterized by microcephaly and growth defects, while its overexpression has been observed in certain cancers. Validated DDX11 antibodies are essential for distinguishing between wild-type and dysfunctional variants, as well as exploring its potential as a therapeutic target.

Most commercial DDX11 antibodies are raised against specific epitopes (e.g., N-terminal or helicase domains) in hosts like rabbits or mice. Rigorous validation, including siRNA knockdown or knockout controls, ensures specificity. Their applications span basic research on genome maintenance to clinical studies on cancer progression, underscoring DDX11's significance in cellular homeostasis and disease pathology.

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关键字: DDX11抗体;DDX11;DDX11 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
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