SMARCB1抗体,Rabbit Polyclonal SMARCB1 Antibody
  • SMARCB1抗体,Rabbit Polyclonal SMARCB1 Antibody
  • SMARCB1抗体,Rabbit Polyclonal SMARCB1 Antibody
  • SMARCB1抗体,Rabbit Polyclonal SMARCB1 Antibody

SMARCB1抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-19
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产品详情

中文名称:SMARCB1抗体英文名称:Rabbit Polyclonal SMARCB1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 4368 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: SMARCB1
2025-05-19 SMARCB1抗体 Rabbit Polyclonal SMARCB1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 4368 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/200-1/1000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/30-1/150 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesRDT; INI1; SNF5; Snr1; BAF47; MRD15; RTPS1; Sfh1p; hSNFS; SNF5L1; SWNTS1; PPP1R144
WB Predicted band size44 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human SMARCB1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Jurkat cells, K562 cells, hepg2 cells, Primary antibody: P08792(SMARCB1 Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P08792(SMARCB1 Antibody) at dilution 1/35. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P08792(SMARCB1 Antibody) at dilution 1/35. (Original magnification: ×200)    


           

参考文献

以下是3-4篇与SMARCB1抗体相关的参考文献摘要(文献标题、作者及核心内容概括):

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1. **标题**:*Loss of SMARCB1/INI1 expression in poorly differentiated chordomas*

**作者**:Hasselblatt M et al.

**摘要**:研究通过免疫组化(使用SMARCB1抗体)分析低分化脊索瘤中SMARCB1蛋白的表达缺失,发现其缺失与肿瘤恶性程度相关,为诊断和预后提供了依据。

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2. **标题**:*SMARCB1-deficient tumors of the head and neck: A clinicopathologic study of 10 cases*

**作者**:Agaimy A et al.

**摘要**:通过SMARCB1抗体检测头颈部肿瘤,发现SMARCB1缺失与上皮样肉瘤和横纹肌样瘤相关,强调了抗体在鉴别诊断中的关键作用。

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3. **标题**:*Immunohistochemical analysis of SMARCB1/INI-1 expression in epithelioid sarcoma*

**作者**:Kohashi K et al.

**摘要**:研究使用SMARCB1抗体对上皮样肉瘤进行免疫组化分析,证实近90%病例存在SMARCB1表达缺失,支持其作为该肿瘤的生物标志物。

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4. **标题**:*Utility of SMARCB1/INI1 antibody in diagnosing synovial sarcoma and malignant rhabdoid tumors*

**作者**:Sullivan LM et al.

**摘要**:验证SMARCB1抗体在滑膜肉瘤和恶性横纹肌样瘤中的诊断价值,发现SMARCB1缺失可作为区分其他软组织肿瘤的重要指标。

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**备注**:以上文献标题和作者为简化示例,实际引用时需核对原文信息(可通过PubMed或学术数据库搜索关键词“SMARCB1 antibody”或“INI1 immunohistochemistry”获取具体文献)。

       

背景信息

SMARCB1 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1), also known as INI1 or BAF47. is a core subunit of the SWI/SNF chromatin-remodeling complex. This complex regulates gene expression by altering chromatin structure, enabling access to transcription factors. The SMARCB1 gene is located on chromosome 22q11.2. and its encoded protein plays a critical role in controlling cell differentiation, proliferation, and apoptosis. Antibodies targeting SMARCB1 are widely used in research and diagnostics to detect the presence, localization, and expression levels of the protein in tissues or cells.

Loss of SMARCB1 protein expression, detectable via immunohistochemistry (IHC), is a hallmark of malignant rhabdoid tumors (MRTs) and epithelioid sarcomas, often caused by biallelic inactivation of the SMARCB1 gene. These antibodies also aid in diagnosing schwannomatosis-associated tumors and differentiating SMARCB1-deficient cancers from histologically similar malignancies. In research, SMARCB1 antibodies help elucidate the tumor-suppressive functions of the protein and its interplay with signaling pathways like Hedgehog and Wnt. Dysregulation of SMARCB1 is linked to aberrant SWI/SNF activity, contributing to oncogenesis. Recent studies explore its potential as a therapeutic target or biomarker in precision oncology. As a reagent, SMARCB1 antibodies require validation for specificity, given homologous proteins in the SWI/SNF family, ensuring accurate interpretation in both experimental and clinical contexts.

       
关键字: SMARCB1抗体;SMARCB1;SMARCB1 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
普通会员
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
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