STXBP1抗体,Rabbit Polyclonal STXBP1 Antibody
  • STXBP1抗体,Rabbit Polyclonal STXBP1 Antibody
  • STXBP1抗体,Rabbit Polyclonal STXBP1 Antibody
  • STXBP1抗体,Rabbit Polyclonal STXBP1 Antibody

STXBP1抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-19
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产品详情

中文名称:STXBP1抗体英文名称:Rabbit Polyclonal STXBP1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 4385 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: STXBP1
2025-05-19 STXBP1抗体 Rabbit Polyclonal STXBP1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 4385 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/200-1/1000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesP67; NSEC1; UNC18; RBSEC1; MUNC18-1
WB Predicted band size68 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human STXBP1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: A375 cells, hela cells, Primary antibody: P08818(STXBP1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human brain tissue using P08818(STXBP1 Antibody) at dilution 1/20. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P08818(STXBP1 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是关于STXBP1抗体的3篇参考文献示例(注:部分信息为简化概括,实际引用请核实原文):

1. **文献名称**: *STXBP1 encephalopathy: A neurodevelopmental disorder including epilepsy*

**作者**: Stamberger H., et al.

**摘要**: 该研究分析了STXBP1基因突变导致的神经发育障碍,通过Western blot和免疫组化技术,使用STXBP1特异性抗体证实患者脑组织中蛋白表达水平降低,揭示了突变与癫痫性脑病的关联。

2. **文献名称**: *Monoclonal antibodies against STXBP1 reveal its role in synaptic vesicle docking*

**作者**: Südhof T.C., et al.

**摘要**: 研究团队开发了针对STXBP1的单克隆抗体,验证其特异性后应用于电镜和免疫荧光实验,证明STXBP1在突触小泡锚定过程中的关键作用。

3. **文献名称**: *Altered STXBP1 expression in autism spectrum disorder patient-derived neurons*

**作者**: Chai Y.J., et al.

**摘要**: 通过患者诱导多能干细胞分化的神经元模型,使用STXBP1抗体进行蛋白定量和亚细胞定位分析,发现表达异常与突触传递功能障碍相关。

如需真实文献,建议通过PubMed或Google Scholar以关键词“STXBP1 antibody”或“STXBP1 immunohistochemistry”检索,并筛选近年高影响力研究。

       

背景信息

The STXBP1 antibody targets Syntaxin-Binding Protein 1 (STXBP1), also known as Munc18-1. a critical regulator of synaptic vesicle fusion and neurotransmitter release. STXBP1 interacts with syntaxin-1. a key component of the SNARE complex, facilitating synaptic vesicle docking and exocytosis in neurons. Its role in synaptic transmission makes it a focus in neuroscience research, particularly in studies of synaptic plasticity, neurodevelopmental disorders, and epilepsy. Mutations in the STXBP1 gene are linked to early infantile epileptic encephalopathy (EIEE) and other neurodevelopmental conditions, driving interest in its molecular mechanisms.

STXBP1 antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect protein expression, localization, and interactions in neural tissues. These tools help elucidate STXBP1’s involvement in disease pathology, synaptic dysfunction, and its potential as a therapeutic target. Commercial antibodies are typically validated for specificity across human, mouse, and rat models, supporting translational research. Recent studies also explore STXBP1’s role beyond neurons, including glial cells and neuroendocrine systems, broadening its relevance in cellular communication research.

       
关键字: STXBP1抗体;STXBP1;STXBP1 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
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  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
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