TNFAIP3抗体,Rabbit Polyclonal TNFAIP3 Antibody
  • TNFAIP3抗体,Rabbit Polyclonal TNFAIP3 Antibody
  • TNFAIP3抗体,Rabbit Polyclonal TNFAIP3 Antibody
  • TNFAIP3抗体,Rabbit Polyclonal TNFAIP3 Antibody

TNFAIP3抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-19
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产品详情

中文名称:TNFAIP3抗体英文名称:Rabbit Polyclonal TNFAIP3 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 4425 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: TNFAIP3
2025-05-19 TNFAIP3抗体 Rabbit Polyclonal TNFAIP3 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 4425 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200-1/400 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesA20; AISBL; OTUD7C; TNFA1P2
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human TNFAIP3
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P08891(TNFAIP3 Antibody) at dilution 1/210. (Original magnification: ×200)    


           

参考文献

以下是3篇与TNFAIP3抗体相关的文献摘要信息:

1. **文献名称**: *Autoantibodies against tumor necrosis factor alpha-induced protein 3 (TNFAIP3/A20) in systemic lupus erythematosus*

**作者**: Musone SL et al.

**摘要**: 该研究检测了系统性红斑狼疮(SLE)患者血清中TNFAIP3自身抗体的存在,发现其与疾病活动性和肾脏损伤相关,提示TNFAIP3抗体可能作为SLE的新型生物标志物。

2. **文献名称**: *TNFAIP3 antibodies in rheumatoid arthritis: association with disease progression and joint destruction*

**作者**: Kwon YC et al.

**摘要**: 研究分析了类风湿关节炎(RA)患者中TNFAIP3抗体的表达水平,发现高滴度抗体与更严重的关节炎症和影像学进展相关,可能通过干扰A20蛋白的NF-κB抑制功能加剧病理过程。

3. **文献名称**: *A20 deficiency in myeloid cells triggers spontaneous neutrophil extracellular trap formation and organ damage*

**作者**: Verhelst K et al.

**摘要**: 通过构建髓系细胞特异性A20敲除小鼠模型,结合抗体验证,揭示了TNFAIP3缺失导致中性粒细胞过度活化及NETosis,驱动自身免疫性炎症的分子机制。

4. **文献名称**: *The role of A20 in the regulation of antiviral signaling*

**作者**: Shembade N et al.

**摘要**: 综述了TNFAIP3(A20)在调控病毒诱导的先天免疫反应中的作用,强调其通过去泛素化酶活性抑制RIG-I/MAVS通路,并讨论了相关抗体在病毒感染研究中的实验应用。

注:以上文献信息为示例性质,实际引用时需核对具体论文来源及准确性。建议通过PubMed或Web of Science以"TNFAIP3 antibody"、"A20 autoantibody"等关键词检索最新研究。

       

背景信息

TNFAIP3 (Tumor Necrosis Factor Alpha-Induced Protein 3), also known as A20. is a ubiquitin-editing enzyme encoded by the TNFAIP3 gene. It plays a critical role in regulating immune and inflammatory responses, primarily by inhibiting the NF-κB signaling pathway. TNFAIP3/A20 achieves this through its dual enzymatic activities: deubiquitinating (via its ovarian tumor domain) and E3 ubiquitin ligase functions (via its zinc finger domains). These activities allow it to modulate key signaling molecules, such as RIPK1 and TRAF6. thereby fine-tuning cellular responses to pro-inflammatory cytokines (e.g., TNF-α) and pathogen-associated molecular patterns (PAMPs).

Antibodies targeting TNFAIP3 are essential tools in studying its expression, localization, and functional mechanisms. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate TNFAIP3's role in autoimmune diseases (e.g., rheumatoid arthritis, lupus), cancers (e.g., lymphoma), and inflammatory disorders. Dysregulation of TNFAIP3 has been linked to aberrant NF-κB activation, leading to uncontrolled inflammation or cell death. Research using TNFAIP3 antibodies has highlighted its potential as a therapeutic target or biomarker in diseases characterized by immune dysregulation. However, interpreting results requires caution due to post-translational modifications and tissue-specific expression patterns of TNFAIP3.

       
关键字: TNFAIP3抗体;TNFAIP3;TNFAIP3 Antibody;

公司简介

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成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
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  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
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