The MAT2B antibody is designed to detect methionine adenosyltransferase 2β (MAT2B), a regulatory subunit of the enzyme methionine adenosyltransferase II (MAT II). MAT II catalyzes the synthesis of S-adenosylmethionine (SAMe), a universal methyl donor critical for cellular methylation reactions, including DNA, protein, and lipid modifications. MAT2B exists in two splice variants (V1 and V2) and plays a key role in modulating MAT II activity and SAMe levels, particularly in proliferating cells. Dysregulation of MAT2B has been linked to metabolic disorders, liver diseases, and cancers, where its overexpression may promote cell proliferation, survival, and chemoresistance by influencing SAMe-dependent pathways and interacting with signaling molecules like HuR and β-catenin.
MAT2B antibodies are widely used in research to study MAT2B expression, localization, and function in various tissues and disease models. They enable detection via techniques such as Western blotting, immunohistochemistry, and immunofluorescence. These tools help elucidate MAT2B’s role in cellular processes, including redox regulation, apoptosis, and epigenetic modulation, offering insights into its potential as a therapeutic target. Researchers also explore its association with conditions like hepatocellular carcinoma, Alzheimer’s disease, and diabetes, where SAMe metabolism imbalances contribute to pathogenesis.