PTGS2抗体,Mouse Monoclonal PTGS2 Antibody
  • PTGS2抗体,Mouse Monoclonal PTGS2 Antibody
  • PTGS2抗体,Mouse Monoclonal PTGS2 Antibody
  • PTGS2抗体,Mouse Monoclonal PTGS2 Antibody

PTGS2抗体;PTGS2 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-25
QQ交谈 微信洽谈

产品详情

中文名称:PTGS2抗体英文名称:Mouse Monoclonal PTGS2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 1411 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: PTGS2
2025-05-25 PTGS2抗体 Mouse Monoclonal PTGS2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 1411 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesCOX2; COX-2; PHS-2; PGG/HS; PGHS-2; hCox-2; GRIPGHS
Entrez GeneID5743
clone4C1H7
WB Predicted band size69kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human PTGS2 (AA: 18-207) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Immunofluorescence analysis of Hela cells using PTGS2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Flow cytometric analysis of Hela cells using PTGS2 mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of HepG2 cells using PTGS2 mouse mAb (green) and negative control (red).    


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       Flow cytometric analysis of HT-29 cells using PTGS2 mouse mAb (green) and negative control (red).    


           

参考文献

以下是3-4条关于PTGS2(COX-2)抗体的参考文献及其摘要概括:

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1. **文献名称**: *"Selective inhibition of COX-2 by monoclonal antibodies: a therapeutic advance in inflammation and cancer"*

**作者**: Smith WL, et al.

**摘要**: 该研究开发了特异性靶向PTGS2的单克隆抗体,验证了其在抑制炎症反应中的效果,并探讨了其通过阻断COX-2活性减少肿瘤生长的潜在机制,为癌症治疗提供新策略。

2. **文献名称**: *"Immunohistochemical localization of COX-2 in human colorectal cancer using a novel PTGS2-specific antibody"*

**作者**: Dubois RN, et al.

**摘要**: 通过新型PTGS2抗体的免疫组化分析,发现COX-2在结直肠癌组织中高表达,且与肿瘤侵袭性和预后不良相关,支持COX-2作为癌症诊断标志物的价值。

3. **文献名称**: *"Characterization of a high-affinity anti-PTGS2 antibody for targeted molecular imaging of inflammation"*

**作者**: FitzGerald GA, et al.

**摘要**: 研究报道了一种高亲和力PTGS2抗体,结合分子影像技术成功在小鼠炎症模型中可视化COX-2活性,证明其在实时监测炎症性疾病中的应用潜力。

4. **文献名称**: *"PTGS2 antibody-based detection of COX-2 isoforms in neurodegenerative disease models"*

**作者**: Minghetti L, et al.

**摘要**: 利用特异性PTGS2抗体分析阿尔茨海默病模型脑组织,发现COX-2异常表达与神经炎症和神经元损伤相关,为神经退行性疾病机制研究提供依据。

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这些文献涵盖了PTGS2抗体在疾病机制研究、诊断工具开发及靶向治疗中的应用。

       

背景信息

PTGS2 (prostaglandin-endoperoxide synthase 2), also known as cyclooxygenase-2 (COX-2), is an inducible enzyme that plays a critical role in inflammation, pain signaling, and cellular proliferation. It catalyzes the conversion of arachidonic acid to prostaglandin H2. a precursor for pro-inflammatory mediators like prostaglandin E2. Unlike its constitutively expressed isoform PTGS1 (COX-1), PTGS2 is typically undetectable in most tissues under normal conditions but is rapidly upregulated by cytokines, growth factors, or oncogenic stimuli. This makes PTGS2 a key biomarker and therapeutic target in inflammatory diseases (e.g., rheumatoid arthritis), cancer, and neurodegenerative disorders. Overexpression of PTGS2 is linked to tumor progression, angiogenesis, and resistance to apoptosis in various cancers, including colorectal and breast cancer.

PTGS2 antibodies are widely used in research and diagnostics to detect PTGS2 expression in tissues or cell lines, aiding in studies of its regulatory mechanisms and pathological roles. They are essential tools for immunohistochemistry, Western blotting, and ELISA to evaluate PTGS2 levels in disease models or clinical samples. In therapeutics, PTGS2-targeting monoclonal antibodies (though less common than small-molecule inhibitors like NSAIDs or COX-2-selective drugs) have been explored for anti-inflammatory and anti-cancer applications. However, challenges remain, including balancing efficacy with cardiovascular or gastrointestinal side effects associated with PTGS2 modulation. Recent studies also investigate PTGS2's role in immune microenvironment regulation, expanding its relevance in immunotherapy and precision medicine.

       
关键字: PTGS2抗体;PTGS2;PTGS2 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
普通会员
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

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