CTBP2抗体;CTBP2 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P07714(PROS1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P07714(PROS1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The C-terminal binding protein 2 (CTBP2) is a transcriptional co-repressor belonging to the CTBP family, which plays a critical role in regulating gene expression by interacting with DNA-binding proteins and chromatin-modifying complexes. CTBP2 is structurally related to CTBP1. sharing a conserved NAD+-binding dehydrogenase domain, though their functions can diverge. It is involved in repressing tumor suppressor genes and modulating cellular processes such as apoptosis, differentiation, and epithelial-mesenchymal transition (EMT). CTBP2’s activity is influenced by cellular metabolic states, as its co-repressor function is regulated by NAD+/NADH levels, linking cellular energy status to transcriptional regulation.

Antibodies targeting CTBP2 are widely used in research to study its expression, localization, and interactions in normal and pathological contexts. In cancer biology, CTBP2 overexpression has been implicated in tumor progression, metastasis, and therapy resistance in various malignancies, including colorectal, breast, and ovarian cancers. Its association with Wnt, Notch, and TGF-β signaling pathways makes it a focus for understanding oncogenic mechanisms. CTBP2 antibodies are essential tools for techniques like Western blotting, immunohistochemistry, and ChIP-seq, aiding in the identification of its role as a potential biomarker or therapeutic target. Dysregulation of CTBP2 is also linked to developmental disorders, highlighting its broader biological significance.