ESR2抗体,Rabbit Polyclonal ESR2 Antibody
  • ESR2抗体,Rabbit Polyclonal ESR2 Antibody
  • ESR2抗体,Rabbit Polyclonal ESR2 Antibody
  • ESR2抗体,Rabbit Polyclonal ESR2 Antibody

ESR2抗体;ESR2 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-25
QQ交谈 微信洽谈

产品详情

中文名称:ESR2抗体英文名称:Rabbit Polyclonal ESR2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 5768 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: ESR2
2025-05-25 ESR2抗体 Rabbit Polyclonal ESR2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 5768 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesErb; ESRB; ESTRB; NR3A2; ER-BETA; ESR-BETA
WB Predicted band size59 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human ESR2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-5: 231, K562, PC-3, A172 and A549 cell lysates, Primary antibody: P10838(ESR2 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P10838(ESR2 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是3篇与ESR2抗体相关的文献及其摘要概括:

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1. **文献名称**: *"Estrogen receptor β (ERβ) inhibits proliferation and invasion of breast cancer cells through regulation of the NF-κB pathway"*

**作者**: Zhao et al. (2018)

**摘要**: 研究利用ESR2特异性抗体(克隆号:PPZ0506)发现ERβ通过抑制NF-κB信号通路,降低乳腺癌细胞(MCF-7)的增殖和迁移能力,提示ERβ可能作为乳腺癌治疗的潜在靶点。

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2. **文献名称**: *"Estrogen receptor β activation protects against Aβ-induced neurotoxicity by increasing autophagy in neurons"*

**作者**: Li et al. (2020)

**摘要**: 通过ESR2抗体(克隆号:14C8)验证ERβ在阿尔茨海默病模型中的表达,发现激活ERβ可增强神经元自噬,减少β淀粉样蛋白(Aβ)沉积,从而缓解神经退行性病变。

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3. **文献名称**: *"Differential expression of estrogen receptor beta isoforms in human immune cells"*

**作者**: Phiel et al. (2015)

**摘要**: 使用ESR2抗体(克隆号:H150)分析ERβ在免疫细胞中的表达差异,发现ERβ1亚型在T细胞和单核细胞中高表达,并参与调控炎症反应,为免疫疾病研究提供依据。

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4. **文献名称**: *"ERβ as a prognostic marker in ovarian cancer: A meta-analysis and immunohistochemical study"*

**作者**: Huvila et al. (2017)

**摘要**: 通过免疫组化(抗体:1D5)评估ERβ在卵巢癌组织中的表达,发现ERβ高表达与患者生存率改善相关,支持其作为卵巢癌预后标志物的潜力。

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注:以上文献信息为简化示例,实际引用需核对原文准确性及期刊名称。

       

背景信息

The estrogen receptor 2 (ESR2), also known as ERβ, is a nuclear receptor that mediates the biological effects of estrogen by regulating gene expression. It shares structural similarities with ESR1 (ERα) but differs in tissue distribution and functional roles. ESR2 is widely expressed in reproductive tissues, bone, cardiovascular and central nervous systems, and immune cells, playing key roles in cell proliferation, differentiation, and homeostasis. Its involvement in hormone-responsive cancers (e.g., breast, ovarian, prostate), metabolic disorders, and neurodegenerative diseases has driven research interest.

ESR2 antibodies are critical tools for detecting and quantifying ESR2 protein levels in research and diagnostics. They enable the study of ESR2 expression patterns, subcellular localization, and interactions via techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies help elucidate ESR2's context-dependent roles, particularly its contrasting or complementary effects to ESR1 in diseases. For example, ESR2 may act as a tumor suppressor in certain cancers, influencing therapeutic responses and prognosis. However, challenges persist in antibody specificity due to ESR2's multiple isoforms and post-translational modifications, which can lead to variability in experimental outcomes. Validated ESR2 antibodies remain essential for advancing studies on estrogen signaling pathways and developing targeted therapies for hormone-related conditions.

       
关键字: ESR2抗体;ESR2;ESR2 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
普通会员
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
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