ZFP91抗体,Mouse Monoclonal ZFP91 Antibody
  • ZFP91抗体,Mouse Monoclonal ZFP91 Antibody

ZFP91抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-12
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产品详情

中文名称:ZFP91抗体英文名称:Mouse Monoclonal ZFP91 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 894 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: ZFP91
2025-05-12 ZFP91抗体 Mouse Monoclonal ZFP91 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 894 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/100 - 1/500 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesPZF; DMS-8; DSM-8; FKSG11; ZFP-91; ZNF757
Entrez GeneID80829
clone8C3D5
WB Predicted band size63.4kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human ZFP91 (AA: 162-304) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Western blot analysis using ZFP91 mouse mAb against Jurkat (1), A431 (2), HepG2 (3), HEK293 (4), A549 (5), and PC-3 (6) cell lysate.    


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       Immunofluorescence analysis of Hela cells using ZFP91 mouse mAb. Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.    


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       Immunofluorescence analysis of Hela cells using ZFP91 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Flow cytometric analysis of Hela cells using ZFP91 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using ZFP91 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using ZFP91 mouse mAb with DAB staining.    


           

参考文献

以下是关于ZFP91抗体的模拟参考文献示例(信息为模拟生成,建议通过学术数据库进一步检索核实):

1. **文献名称**:ZFP91 regulates NF-κB signaling in cancer by mediating proteasomal degradation of IκBα

**作者**:Li X, et al.

**摘要**:该研究揭示了ZFP91通过泛素-蛋白酶体系统促进IκBα降解,激活NF-κB通路,从而促进肿瘤细胞增殖。研究使用特异性ZFP91抗体验证其蛋白表达与结肠癌进展的相关性。

2. **文献名称**:ZFP91 is required for antiviral innate immunity by interacting with MAVS

**作者**:Wang Y, et al.

**摘要**:本文发现ZFP91通过与线粒体抗病毒信号蛋白(MAVS)相互作用增强Ⅰ型干扰素表达。研究利用ZFP91抗体进行免疫共沉淀实验,证明其在抗病毒天然免疫中的关键作用。

3. **文献名称**:ZFP91-Catalyzed Nonproteolytic Ubiquitination Promotes Autophagy-Lysosome Degradation

**作者**:Zhang Q, et al.

**摘要**:该研究提出ZFP91作为非经典E3泛素连接酶,调控自噬底物的泛素化及溶酶体降解。通过ZFP91抗体敲低实验,证实其在代谢应激下维持细胞稳态的功能。

4. **文献名称**:Targeting ZFP91 by a monoclonal antibody suppresses tumor growth in hepatocellular carcinoma

**作者**:Chen L, et al.

**摘要**:研究团队开发了靶向ZFP91的单克隆抗体,体内实验显示其可通过抑制Wnt/β-catenin通路显著降低肝癌小鼠模型的肿瘤负荷,提示ZFP91抗体的治疗潜力。

       

背景信息

The ZFP91 antibody targets the ZFP91 protein, a zinc finger protein encoded by the ZFP91 gene in humans. Zinc finger proteins are characterized by conserved structural motifs that facilitate DNA or RNA binding, often playing roles in transcriptional regulation, ubiquitination, or signal transduction. ZFP91. also identified as a non-canonical E3 ubiquitin ligase, has been implicated in modulating critical cellular processes, including NF-κB and MAPK signaling pathways, apoptosis, and immune responses. It interacts with substrates like Roquin-1 and NEMO, influencing protein stability and downstream signaling events. Dysregulation of ZFP91 is linked to diseases such as cancer, autoimmune disorders, and viral infections. For instance, it promotes tumorigenesis in certain cancers by enhancing cell proliferation or inhibiting apoptosis. Antibodies against ZFP91 are essential tools for studying its expression, localization, and molecular interactions via techniques like Western blotting, immunoprecipitation, and immunofluorescence. Recent research highlights its potential as a therapeutic target, particularly in oncology and inflammation-related pathologies. However, its precise mechanisms remain under investigation, necessitating further functional studies to elucidate its role in health and disease.
       


关键字: ZFP91抗体;ZFP91;ZFP91 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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