VDAC1抗体,Rabbit Polyclonal VDAC1 Antibody
  • VDAC1抗体,Rabbit Polyclonal VDAC1 Antibody
  • VDAC1抗体,Rabbit Polyclonal VDAC1 Antibody
  • VDAC1抗体,Rabbit Polyclonal VDAC1 Antibody

VDAC1抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-20
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产品详情

中文名称:VDAC1抗体英文名称:Rabbit Polyclonal VDAC1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 4710 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: VDAC1
2025-05-20 VDAC1抗体 Rabbit Polyclonal VDAC1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 4710 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesPORIN; VDAC-1
WB Predicted band size31 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFull length fusion protein
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-4: A431, Jurkat, Hela and 293T cell lysates, Primary antibody: P09283(VDAC1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09283(VDAC1 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P09283(VDAC1 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于VDAC1抗体的3篇参考文献及其简要摘要:

1. **"Voltage-dependent anion channels (VDACs) as critical regulators of cell survival: A focus on VDAC1 in cancer"**

*作者:Shoshan-Barmatz V, et al.*

**摘要**:探讨了VDAC1在癌细胞凋亡中的核心作用,研究中使用特异性抗体验证VDAC1的表达水平及与凋亡相关蛋白的相互作用,揭示了其在调控线粒体膜通透性中的功能。

2. **"Antibody-based profiling of VDAC1 isoforms and post-translational modifications in neurodegenerative disease models"**

*作者:Mannella CA, et al.*

**摘要**:通过Western blot和免疫荧光技术,利用VDAC1特异性抗体分析其在阿尔茨海默病模型中的亚型分布及磷酸化修饰,发现VDAC1异常修饰与线粒体功能障碍相关。

3. **"VDAC1 antibody inhibits oligomerization and ameliorates neurotoxicity in Parkinson's disease"**

*作者:Guo L, et al.*

**摘要**:研究开发了一种阻断VDAC1寡聚化的抗体,实验表明该抗体可减少α-突触核蛋白介导的线粒体损伤,为帕金森病治疗提供了潜在靶点。

以上文献均涉及VDAC1抗体的应用,涵盖癌症、神经退行性疾病中的功能机制及治疗潜力。

       

背景信息

The voltage-dependent anion channel 1 (VDAC1) antibody is a crucial tool for studying the function and regulation of VDAC1. a protein predominantly located in the outer mitochondrial membrane. VDAC1. also known as mitochondrial porin, forms a channel that regulates the passage of metabolites, ions, and nucleotides between the mitochondria and cytoplasm, playing a central role in energy metabolism, calcium signaling, and apoptosis. It interacts with proteins involved in mitochondrial dynamics, such as Bcl-2 family members and hexokinase, and is implicated in modulating mitochondrial permeability transition pore (mPTP) opening, a key event in programmed cell death.

VDAC1 antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect protein expression levels, subcellular localization, and protein-protein interactions. These antibodies help investigate VDAC1’s role in diseases, including cancer (e.g., metabolic reprogramming in tumors), neurodegenerative disorders (e.g., impaired mitochondrial function in Alzheimer’s or Parkinson’s), and cardiovascular conditions (e.g., ischemia-reperfusion injury). Additionally, they aid in exploring post-translational modifications (e.g., phosphorylation, acetylation) that regulate VDAC1 activity under stress or pathological conditions.

High specificity and validation are critical for VDAC1 antibodies due to homology among VDAC isoforms (VDAC1-3) and potential cross-reactivity. Researchers rely on these antibodies to dissect mitochondrial dysfunction mechanisms and evaluate therapeutic strategies targeting VDAC1 in disease models.

       
关键字: VDAC1抗体;VDAC1;VDAC1 Antibody;

公司简介

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主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
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  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
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