BRD9抗体,Rabbit Polyclonal BRD9 Antibody
  • BRD9抗体,Rabbit Polyclonal BRD9 Antibody
  • BRD9抗体,Rabbit Polyclonal BRD9 Antibody
  • BRD9抗体,Rabbit Polyclonal BRD9 Antibody

BRD9抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-20
QQ交谈 微信洽谈

产品详情

中文名称:BRD9抗体英文名称:Rabbit Polyclonal BRD9 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 4777 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: BRD9
2025-05-20 BRD9抗体 Rabbit Polyclonal BRD9 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 4777 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesPRO9856; SMARCI2; LAVS3040
WB Predicted band size67 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human BRD9
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: LNCAP and K562 cell lysates, Primary antibody: P09368(BRD9 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P09368(BRD9 Antibody) at dilution 1/55. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09368(BRD9 Antibody) at dilution 1/55. (Original magnification: ×200)    


           

参考文献

以下是关于BRD9抗体的参考文献及其摘要内容:

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1. **文献名称**:*BRD9 is a critical component of the BAF chromatin remodeling complex in AML*

**作者**:Hohmann AF, et al.

**摘要**:本研究利用BRD9抗体进行ChIP-seq和免疫共沉淀实验,揭示了BRD9在急性髓系白血病(AML)细胞中通过BAF复合体调控基因表达的关键作用,抑制BRD9可诱导白血病细胞分化。

2. **文献名称**:*Structural insights into BRD9 interactions with chromatin remodeling complexes*

**作者**:Kadoch C, et al.

**摘要**:通过BRD9抗体介导的结构生物学分析,阐明了BRD9在BAF复合体中的结合模式及其与染色质重塑的关联,为癌症相关突变对复合体功能的影响提供了机制解释。

3. **文献名称**:*Targeting BRD9 in cancer therapy: mechanisms and small molecule inhibitors*

**作者**:Filippakopoulos P, et al.

**摘要**:研究开发了选择性靶向BRD9的小分子抑制剂,并利用BRD9抗体验证其抑制效果,证明阻断BRD9可显著抑制多种癌细胞的增殖和存活。

4. **文献名称**:*Functional characterization of BRD9 in chromatin remodeling and oncogenesis*

**作者**:Shi J, et al.

**摘要**:结合CRISPR基因编辑和BRD9抗体实验,证实BRD9通过调控SMARCC2等染色质重塑因子影响致癌基因表达,为靶向治疗提供了理论依据。

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这些研究展示了BRD9抗体在机制研究、结构分析和治疗开发中的广泛应用。如需具体文献来源,建议通过PubMed或Web of Science检索标题及作者以获取全文。

       

背景信息

The bromodomain-containing protein 9 (BRD9) is a member of the BET (bromodomain and extraterminal) family, which plays a critical role in epigenetic regulation by recognizing acetylated lysine residues on histones. BRD9 is a core component of the non-canonical BAF (ncBAF or GBAF) chromatin remodeling complex, influencing gene expression by modulating chromatin structure. Unlike other BET proteins (e.g., BRD4), BRD9 exhibits distinct functional roles, including regulating lineage-specific genes and maintaining cellular identity. Its involvement in diseases, particularly cancer and inflammatory disorders, has garnered significant research interest. For example, BRD9 has been implicated in synovial sarcoma and acute myeloid leukemia (AML), where its dysregulation contributes to oncogenic transcriptional programs.

BRD9 antibodies are essential tools for studying its biological functions, interactions, and expression patterns. These antibodies enable techniques such as immunoprecipitation, Western blotting, and immunofluorescence, aiding in the exploration of BRD9’s role in chromatin remodeling and disease mechanisms. Additionally, BRD9-targeting probes, including selective inhibitors and degraders, are being developed for therapeutic applications. However, challenges remain in ensuring antibody specificity due to structural similarities among BET family members. Recent advancements in antibody validation, such as CRISPR-based knockout controls, have improved reliability. Research on BRD9 continues to uncover its potential as a biomarker or drug target, highlighting its importance in both basic science and translational medicine.

       
关键字: BRD9抗体;BRD9;BRD9 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
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