**Background of CA11 Antibody**
The CA11 antibody targets carbonic anhydrase XI (CA11), a member of the carbonic anhydrase (CA) enzyme family involved in pH regulation, CO₂ homeostasis, and ion transport. CA11. encoded by the *CA11* gene, is a secreted glycoprotein with a unique structure, featuring a CA catalytic domain and a proteoglycan-like region. While its exact physiological role remains less characterized compared to other CA isoforms (e.g., CA9 or CA12), CA11 is implicated in extracellular matrix remodeling, cell adhesion, and possibly tumorigenesis.
CA11 expression has been detected in various tissues, including the brain, kidney, and reproductive organs, with elevated levels observed in certain cancers, such as renal cell carcinoma and glioblastoma. This tumor-associated expression suggests its potential as a biomarker or therapeutic target. CA11 antibodies are primarily utilized in research to study protein localization, expression patterns, and functional roles in disease models. They enable techniques like immunohistochemistry, Western blotting, and ELISA, aiding in the exploration of CA11's involvement in cancer progression, neurological disorders, and metabolic pathways.
Despite progress, challenges persist in clarifying CA11's precise mechanisms and clinical relevance. Ongoing studies aim to validate its diagnostic utility and assess its suitability for antibody-based therapies or imaging agents in oncology.