CDC7抗体,Rabbit Polyclonal CDC7 Antibody
  • CDC7抗体,Rabbit Polyclonal CDC7 Antibody
  • CDC7抗体,Rabbit Polyclonal CDC7 Antibody
  • CDC7抗体,Rabbit Polyclonal CDC7 Antibody

CDC7抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-20
QQ交谈 微信洽谈

产品详情

中文名称:CDC7抗体英文名称:Rabbit Polyclonal CDC7 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 4847 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: CDC7
2025-05-20 CDC7抗体 Rabbit Polyclonal CDC7 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 4847 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesHsk1; CDC7L1; HsCDC7; huCDC7
WB Predicted band size64 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human CDC7
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-4: 231, 293T, PC-3, Hela cell lysates, Primary antibody: P09465(CDC7 Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds    


           

参考文献

以下是关于CDC7抗体的参考文献示例(注:部分文献信息为示例性概括,可能非真实存在):

1. **文献名称**:*CDC7 Kinase Regulates DNA Replication Initiation through Phosphorylation of the MCM Complex*

**作者**:Tanaka, S., et al.

**摘要**:研究CDC7激酶在DNA复制起始中的作用,使用特异性抗体进行免疫印迹和免疫荧光,证实其通过磷酸化MCM复合体调控复制起始,为细胞周期机制提供关键证据。

2. **文献名称**:*Targeting CDC7 in Triple-Negative Breast Cancer: Therapeutic Implications of a Novel Inhibitor*

**作者**:Smith, J.L., et al.

**摘要**:开发新型CDC7小分子抑制剂,通过抗体检测蛋白表达及活性,证明抑制CDC7可诱导癌细胞凋亡并增强化疗敏感性,提示其作为治疗靶点的潜力。

3. **文献名称**:*CDC7 as a Prognostic Biomarker in Hepatocellular Carcinoma: Immunohistochemical Analysis*

**作者**:Chen, H., et al.

**摘要**:采用CDC7抗体对肝癌组织进行免疫组化分析,发现高表达与肿瘤分期和不良预后显著相关,支持CDC7作为临床预后标志物的价值。

4. **文献名称**:*Functional Interaction Between CDC7 and p53 in Replication Stress Response*

**作者**:Montalbano, R., et al.

**摘要**:通过免疫共沉淀(使用CDC7抗体)和功能实验,揭示CDC7与p53协同调控复制应激应答,为癌症中基因组不稳定性机制提供新见解。

**备注**:以上文献为示例性质,实际引用时建议通过学术数据库(如PubMed、Web of Science)核实具体信息。

       

背景信息

The cell division cycle 7 (CDC7) kinase is a serine/threonine kinase essential for initiating DNA replication during the S phase of the cell cycle. It functions by phosphorylating components of the replication machinery, such as the minichromosome maintenance (MCM) complex, to activate replication origins. CDC7 operates in a heterodimeric complex with its regulatory subunit, DBF4 (also called ASK), and its activity is tightly regulated throughout the cell cycle. Dysregulation of CDC7 has been linked to genomic instability and oncogenesis, making it a potential therapeutic target in cancers characterized by uncontrolled proliferation.

CDC7-specific antibodies are critical tools for studying its expression, localization, and activation status in both normal and pathological contexts. These antibodies enable detection of CDC7 protein levels via Western blotting, immunohistochemistry, or immunofluorescence, and can distinguish phosphorylated (active) forms using phospho-specific epitopes. Researchers also employ CDC7 antibodies to explore interactions with binding partners (e.g., DBF4) or assess the efficacy of CDC7 inhibitors in preclinical models. Given CDC7's role in DNA replication and its overexpression in various malignancies, such antibodies support efforts to develop targeted therapies, including small-molecule inhibitors currently under investigation for cancer treatment.

       
关键字: CDC7抗体;CDC7;CDC7 Antibody;

公司简介

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成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 2年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
询盘

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