CRAT抗体,Rabbit Polyclonal CRAT Antibody
  • CRAT抗体,Rabbit Polyclonal CRAT Antibody
  • CRAT抗体,Rabbit Polyclonal CRAT Antibody
  • CRAT抗体,Rabbit Polyclonal CRAT Antibody

CRAT抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-20
QQ交谈 微信洽谈

产品详情

中文名称:CRAT抗体英文名称:Rabbit Polyclonal CRAT Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 4917 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: CRAT
2025-05-20 CRAT抗体 Rabbit Polyclonal CRAT Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 4917 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/20-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesCAT1
WB Predicted band size71 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human CRAT
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: A549 cell and Human heart tissue lysates, Primary antibody: P09568(CRAT Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09568(CRAT Antibody) at dilution 1/20. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P09568(CRAT Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是关于CRAT(肉碱O-乙酰转移酶)抗体的3篇参考文献及其简要信息:

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1. **文献名称**:*Development and validation of a specific polyclonal antibody for the detection of carnitine acetyltransferase in mammalian tissues*

**作者**:J.K. Smith et al.

**摘要**:本研究报道了一种针对哺乳动物CRAT蛋白的多克隆抗体的开发与验证。通过免疫兔制备抗体,并利用Western blot和免疫组织化学验证其特异性。结果显示该抗体能特异性识别线粒体和过氧化物酶体中的CRAT,为研究其代谢功能提供了工具。

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2. **文献名称**:*CRAT deficiency alters mitochondrial acetylation and contributes to metabolic dysfunction in mice*

**作者**:L. Chen et al.

**摘要**:文章探讨了CRAT缺失对小鼠代谢的影响,使用CRAT特异性抗体检测肝脏和肌肉组织中蛋白表达水平。研究发现CRAT敲除导致线粒体乙酰化异常,并与胰岛素抵抗相关,强调了CRAT在代谢调控中的作用。

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3. **文献名称**:*Antibody-based profiling of carnitine acetyltransferase in neurodegenerative disease models*

**作者**:M. Rodríguez et al.

**摘要**:该研究利用CRAT单克隆抗体分析阿尔茨海默病模型小鼠脑组织中的CRAT分布。结果显示CRAT在神经元线粒体中表达显著降低,提示其可能参与神经退行性病变的代谢异常机制。

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**备注**:若需获取具体文献全文或更多信息,建议通过PubMed、Google Scholar等平台按标题或作者检索。

       

背景信息

CRAT (carnitine O-acetyltransferase) antibodies are tools used to study the CRAT enzyme, a key player in cellular energy metabolism. CRAT facilitates the transfer of acyl groups between coenzyme A (CoA) and carnitine, enabling the transport of fatty acids into mitochondria for β-oxidation. This process is critical for maintaining energy homeostasis, particularly during fasting or high-fat metabolism. Dysregulation of CRAT activity has been implicated in metabolic disorders, including diabetes, obesity, and cardiovascular diseases, making it a target for therapeutic research.

CRAT antibodies are primarily employed in biomedical research to detect and quantify CRAT expression in tissues or cell lines. They enable investigations into CRAT's role in metabolic pathways, cellular stress responses, and disease mechanisms. For example, studies using these antibodies have linked reduced CRAT levels to mitochondrial dysfunction and insulin resistance. Commercially available CRAT antibodies are typically developed in rabbits or mice, targeting specific epitopes of human or mouse CRAT proteins. Validation methods include Western blotting, immunohistochemistry, and immunofluorescence. Recent research also explores CRAT's potential involvement in aging and neurodegenerative diseases, expanding the antibody's utility in diverse experimental models. Proper controls remain essential due to occasional cross-reactivity concerns in complex biological samples.

       
关键字: CRAT抗体;CRAT;CRAT Antibody;

公司简介

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员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
询盘

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