RSU1抗体,Rabbit Polyclonal RSU1 Antibody
  • RSU1抗体,Rabbit Polyclonal RSU1 Antibody
  • RSU1抗体,Rabbit Polyclonal RSU1 Antibody
  • RSU1抗体,Rabbit Polyclonal RSU1 Antibody

RSU1抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-20
QQ交谈 微信洽谈

产品详情

中文名称:RSU1抗体英文名称:Rabbit Polyclonal RSU1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 4968 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: RSU1
2025-05-20 RSU1抗体 Rabbit Polyclonal RSU1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 4968 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesRSP-1
WB Predicted band size32 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human RSU1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-7: Rat heart tissue, Mouse heart tissue, Rat brain tissue, Mouse brain tissue, HEPG2 cell, Jurkat and Lovo cell lysates, Primary antibody: P09638(RSU1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P09638(RSU1 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P09638(RSU1 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于RSU1抗体的3篇参考文献及其摘要概括:

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1. **文献名称**: *"RSU1 regulates cell migration through association with PINCH1 in epithelial cells"*

**作者**: Dougherty GW, et al.

**摘要**: 该研究通过免疫共沉淀和免疫荧光技术,利用RSU1特异性抗体揭示了RSU1蛋白与PINCH1的相互作用,表明其在调控上皮细胞黏着斑形成和迁移中的关键作用,为RSU1在细胞骨架重塑中的功能提供了证据。

2. **文献名称**: *"The Ras suppressor RSU1 inhibits cell migration via attenuation of ERK signaling through interaction with integrin-linked kinase"*

**作者**: Vachon PH, et al.

**摘要**: 研究通过Western blot和免疫染色实验,使用RSU1抗体检测其在多种癌细胞系中的表达,发现RSU1通过抑制ERK信号通路阻碍细胞迁移,提示其作为肿瘤转移抑制因子的潜在机制。

3. **文献名称**: *"RSU1 modulates apoptosis and proliferation in glioblastoma via the Hippo-YAP pathway"*

**作者**: Chen Y, et al.

**摘要**: 本文利用RSU1抗体进行组织免疫组化分析,发现RSU1在胶质母细胞瘤中表达下调,并通过调控Hippo-YAP通路影响肿瘤细胞增殖和凋亡,为靶向RSU1的抗癌治疗提供了新思路。

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以上文献均涉及RSU1抗体的实验应用(如蛋白定位、表达分析及分子机制研究),聚焦于其在细胞迁移、癌症进展中的功能。如需具体期刊信息或发表年份,可进一步补充数据库检索。

       

背景信息

The RSU1 (Ras suppressor protein 1) antibody is a tool used to study the RSU1 protein, a conserved regulator of cell adhesion and migration. Initially identified as a suppressor of Ras-dependent oncogenic transformation, RSU1 interacts with the integrin-mediated signaling pathway by binding to PINCH1 (Particularly Interesting Cys-His-rich protein 1), a component of the integrin-linked kinase (ILK) complex. This interaction links extracellular matrix (ECM) signals to cytoskeletal dynamics, influencing cell spreading, motility, and survival. RSU1’s role in modulating focal adhesion formation and actin cytoskeleton organization highlights its importance in developmental processes, tissue homeostasis, and cancer metastasis.

Research using RSU1 antibodies has revealed its involvement in pathologies such as cancer, where altered RSU1 expression correlates with tumor progression and invasion. For example, reduced RSU1 levels are associated with increased metastasis in breast cancer and melanoma. The antibody is widely employed in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect RSU1 localization and expression patterns in cell lines and tissue samples. Recent studies also explore its potential as a biomarker or therapeutic target. By elucidating RSU1’s regulatory mechanisms in ECM signaling, this antibody aids in understanding cellular responses to mechanical cues and disease pathways, bridging basic cell biology with clinical applications.

       
关键字: RSU1抗体;RSU1;RSU1 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
询盘

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