**Background of SUB1 Antibody**
The SUB1 antibody targets the SUB1 protein (also known as PC4 or SUB1 homolog), a conserved multifunctional regulator involved in transcriptional elongation, RNA processing, and DNA repair. Initially identified in yeast, SUB1 homologs are present in eukaryotes, including humans. Structurally, SUB1 contains a single-strand nucleic acid-binding domain, enabling interactions with RNA and single-stranded DNA.
Functionally, SUB1 modulates RNA polymerase II activity during transcription, facilitates mRNA capping, and participates in termination. It also plays a role in DNA damage response by promoting homologous recombination repair. Dysregulation of SUB1 is linked to cancer, neurodegenerative disorders, and viral infections, highlighting its cellular significance.
The SUB1 antibody is widely used in research to study SUB1's expression, localization, and interactions via techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP). It aids in exploring SUB1's role in gene regulation, stress responses, and disease mechanisms, making it a vital tool for molecular and cancer biology studies.