MPV17抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P10024(MPV17 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The MPV17 antibody is a crucial tool in studying the MPV17 protein, a mitochondrial inner membrane protein encoded by the *MPV17* gene. This protein plays a vital role in maintaining mitochondrial DNA (mtDNA) integrity and regulating oxidative phosphorylation. Mutations in *MPV17* are linked to mitochondrial DNA depletion syndromes (MDDS), particularly hepatocerebral forms characterized by liver dysfunction and neurological impairments. Researchers use MPV17 antibodies to investigate the protein's expression, localization, and functional interactions within mitochondria, aiding in the diagnosis and mechanistic understanding of related disorders.

MPV17 antibodies are widely employed in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect protein levels in tissues or cell lines. Studies also explore MPV17's role beyond genetic diseases, including its potential involvement in mitochondrial dysfunction associated with aging, neurodegenerative diseases, and metabolic disorders. Additionally, research suggests MPV17 may influence cellular responses to oxidative stress and apoptosis, linking it to broader pathophysiological processes. The antibody's specificity and reliability are critical for validating experimental models, such as *MPV17*-knockout mice, which recapitulate human disease phenotypes. By enabling precise tracking of MPV17 expression changes under various conditions, these antibodies contribute to advancing therapeutic strategies, including gene therapy or small-molecule interventions targeting mitochondrial pathways.