SRPK2抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P10216(SRPK2 Antibody) at dilution 1/90. (Original magnification: ×200)    

  
  

Serine/arginine protein kinase 2 (SRPK2) is a member of the SRPK family, which plays a critical role in regulating RNA splicing by phosphorylating serine/arginine (SR)-rich splicing factors. These kinases influence spliceosome assembly and alternative splicing events, thereby modulating gene expression diversity. SRPK2 is highly expressed in the brain and has been implicated in neuronal development, synaptic plasticity, and cognitive functions. Dysregulation of SRPK2 activity is associated with neurological disorders, including Alzheimer’s disease, where aberrant splicing of tau and other proteins may contribute to pathology. Additionally, SRPK2 has been linked to cancer progression, as its overexpression in certain tumors promotes cell proliferation and survival through splicing-mediated oncogenic pathways.

SRPK2 antibodies are essential tools for studying the kinase’s expression, localization, and functional roles. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect SRPK2 levels in tissues or cultured cells. Researchers also employ these antibodies in co-immunoprecipitation assays to explore SRPK2 interactions with splicing factors or other signaling molecules. The development of phospho-specific SRPK2 antibodies has further enabled investigations into its activation state and downstream signaling under physiological or pathological conditions. As therapeutic targeting of splicing kinases gains interest, SRPK2 antibodies also aid in validating drug efficacy and understanding resistance mechanisms in preclinical models.