The SH3BGR (SH3 domain-binding glutamic acid-rich protein) antibody is a tool used to study the SH3BGR protein family, which comprises conserved, small acidic proteins characterized by an SH3-binding domain and a C-terminal glutamic acid-rich region. SH3BGR proteins interact with SH3 domain-containing partners, potentially modulating cellular signaling pathways. While their exact biological roles remain under investigation, studies suggest involvement in tumorigenesis, cardiovascular development, and immune regulation. For example, SH3BGRL3 (a family member) has been implicated as both a tumor suppressor and promoter in different cancers, highlighting context-dependent functions. SH3BGR antibodies are primarily used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect protein expression, localization, and interactions in cells or tissues. Research utilizing these antibodies has revealed differential SH3BGR expression patterns in cancers, developmental disorders, and cardiovascular diseases, suggesting diagnostic or therapeutic relevance. However, functional ambiguity persists due to limited mechanistic studies and conflicting data across experimental models. Commercial SH3BGR antibodies are typically raised against specific epitopes (e.g., human SH3BGR amino acid sequences) and validated for cross-reactivity in designated species. Ongoing research aims to clarify SH3BGR's molecular interactions and disease associations, with antibodies remaining critical reagents for exploring its physiological and pathological roles.