SUSD3 (Sushi domain-containing protein 3) is a member of the SUSD protein family, characterized by conserved sushi domains that mediate protein-protein interactions and cellular signaling. The SUSD3 gene encodes a transmembrane protein implicated in various biological processes, including immune regulation, cell adhesion, and tumorigenesis. While the precise physiological role of SUSD3 remains under investigation, emerging studies highlight its association with cancer progression, particularly in breast and ovarian cancers, where it may modulate tumor microenvironment interactions or metastatic potential.
SUSD3 antibodies are immunological tools developed to detect, quantify, or inhibit the SUSD3 protein in experimental and clinical settings. These antibodies are typically generated using recombinant SUSD3 epitopes or synthetic peptides, enabling applications such as Western blotting, immunohistochemistry (IHC), flow cytometry, and immunofluorescence. In research, SUSD3 antibodies have been employed to explore its expression patterns, subcellular localization, and functional mechanisms. For instance, studies suggest that SUSD3 may act as a tumor suppressor or promoter depending on context, with altered expression levels correlating with patient prognosis.
Recent interest in SUSD3 antibodies also stems from their potential diagnostic and therapeutic utility. In cancer diagnostics, SUSD3 expression profiling could serve as a biomarker for disease stratification. Therapeutically, antibody-mediated targeting of SUSD3 might influence pathways linked to tumor immune evasion or drug resistance. Despite these advances, further validation is required to fully understand SUSD3's role and optimize antibody-based applications in translational medicine.