CCNI抗体,Rabbit Polyclonal CCNI Antibody
  • CCNI抗体,Rabbit Polyclonal CCNI Antibody
  • CCNI抗体,Rabbit Polyclonal CCNI Antibody
  • CCNI抗体,Rabbit Polyclonal CCNI Antibody

CCNI抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-21
QQ交谈 微信洽谈

产品详情

中文名称:CCNI抗体英文名称:Rabbit Polyclonal CCNI Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 5515 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: CCNI
2025-05-21 CCNI抗体 Rabbit Polyclonal CCNI Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 5515 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesCYI; CYC1; CCNI1
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human CCNI
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P10417(CCNI Antibody) at dilution 1/65. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P10417(CCNI Antibody) at dilution 1/65. (Original magnification: ×200)    


           

参考文献

以下是关于CCNI(Cyclin I)抗体的3篇代表性文献的简要概括(内容基于模拟生成,仅供参考):

1. **文献名称**:*Cyclin I protects neurons against amyloid-beta-induced apoptosis*

**作者**:Zhou, X., et al.

**摘要**:研究揭示了Cyclin I在阿尔茨海默病模型中的作用,通过抗体检测发现Cyclin I与CDK5结合抑制神经元凋亡,提示其可能通过抗凋亡通路发挥神经保护作用。

2. **文献名称**:*Expression and prognostic significance of Cyclin I in breast cancer*

**作者**:Smith, J., et al.

**摘要**:利用CCNI抗体分析乳腺癌组织样本,发现Cyclin I高表达与患者生存率负相关,提示其可作为潜在肿瘤标志物及治疗靶点。

3. **文献名称**:*Cyclin I modulates DNA damage response in renal cells*

**作者**:Malik, R., et al.

**摘要**:通过免疫沉淀和Western blot(使用CCNI抗体)证实Cyclin I参与肾细胞DNA损伤修复调控,缺失会加剧氧化应激导致的细胞周期停滞。

4. **文献名称**:*Cyclin I-CDK5 interaction in post-mitotic neurons*

**作者**:Johnson, A., et al.

**摘要**:研究利用CCNI抗体探究Cyclin I与CDK5的互作机制,发现该复合物在神经元分化中的关键作用,为神经退行性疾病提供分子机制解释。

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**注**:以上文献信息为示例性虚构内容,实际研究中请通过PubMed、Web of Science等数据库检索真实文献。

       

背景信息

CCNI (Cyclin I) is a member of the cyclin protein family, known for regulating cell cycle progression by interacting with cyclin-dependent kinases (CDKs). Unlike classical cyclins such as Cyclin D or B, Cyclin I exhibits distinct expression patterns and functional roles. It is primarily expressed in post-mitotic cells, including neurons and kidney podocytes, suggesting involvement in non-proliferative processes. Studies reveal that Cyclin I forms complexes with CDK5. a kinase linked to neuronal signaling and survival, rather than canonical cell cycle CDKs. This interaction is critical for modulating apoptosis; Cyclin I overexpression inhibits caspase activation, enhancing cell survival under stress conditions like oxidative damage or DNA injury.

Research highlights its role in neurodegenerative diseases and kidney disorders. For instance, reduced Cyclin I levels correlate with increased neuronal death in Alzheimer's disease models, while mutations are implicated in glomerular dysfunction. CCNI antibodies, essential tools in these studies, enable detection of Cyclin I expression in tissues and cell lines, facilitating investigations into its molecular mechanisms. They are widely used in Western blotting, immunohistochemistry, and co-immunoprecipitation assays to explore Cyclin I-CDK5 interactions and downstream pathways. Recent interest also focuses on its potential as a therapeutic target or biomarker in diseases marked by dysregulated apoptosis. Despite progress, questions remain about its tissue-specific regulation and broader signaling networks.

       
关键字: CCNI抗体;CCNI;CCNI Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
询盘

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