LYAR抗体,Rabbit Polyclonal LYAR Antibody
  • LYAR抗体,Rabbit Polyclonal LYAR Antibody
  • LYAR抗体,Rabbit Polyclonal LYAR Antibody
  • LYAR抗体,Rabbit Polyclonal LYAR Antibody

LYAR抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-21
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产品详情

中文名称:LYAR抗体英文名称:Rabbit Polyclonal LYAR Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 5516 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: LYAR
2025-05-21 LYAR抗体 Rabbit Polyclonal LYAR Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 5516 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesZLYAR; ZC2HC2
WB Predicted band size44 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human LYAR
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: LOVO cell lysate, Primary antibody: P10419(LYAR Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P10419(LYAR Antibody) at dilution 1/140. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P10419(LYAR Antibody) at dilution 1/140. (Original magnification: ×200)    


           

参考文献

以下是基于LYAR抗体相关研究的模拟参考文献(文献信息为示例,非真实存在):

1. **"LYAR promotes hepatocellular carcinoma progression by regulating ribosome biogenesis"**

*作者:Zhang L, et al. (2021)*

摘要:研究发现LYAR在肝癌组织中高表达,通过调控核糖体生物合成通路促进肿瘤细胞增殖,其抗体被用于验证LYAR蛋白在临床样本中的表达水平及预后关联。

2. **"LYAR interacts with nucleophosmin to maintain embryonic stem cell pluripotency"**

*作者:Wang H, et al. (2019)*

摘要:利用LYAR特异性抗体进行免疫共沉淀实验,揭示LYAR通过与核磷蛋白(NPM1)相互作用维持胚胎干细胞的自我更新能力,沉默LYAR导致多能性丧失。

3. **"Targeting LYAR inhibits acute myeloid leukemia through p53-dependent apoptosis"**

*作者:Liu Y, et al. (2023)*

摘要:开发针对LYAR的单克隆抗体,证明其可通过激活p53依赖性凋亡通路抑制白血病细胞生长,为LYAR作为血液肿瘤治疗靶点提供实验依据。

4. **"LYAR antibody-based screening identifies its role in DNA damage repair"**

*作者:Chen X, et al. (2017)*

摘要:通过LYAR抗体的免疫荧光染色,发现LYAR定位于细胞核并参与DNA损伤修复过程,其缺失导致基因组不稳定性和放疗敏感性升高。

注:以上内容为模拟文献,实际研究需通过学术数据库(如PubMed)检索真实发表的论文。

       

背景信息

LYAR (Ly-1 antibody reactive) is a nucleolar protein first identified through its reactivity with the Ly-1 antibody, originally raised against murine lymphocyte surface antigens. It belongs to the zinc finger protein family, characterized by a C-terminal C2H2-type zinc finger domain, which suggests roles in nucleic acid binding or protein interactions. LYAR is evolutionarily conserved and implicated in ribosome biogenesis, cell proliferation, and embryonic development. Studies reveal its involvement in regulating rRNA processing and ribosome assembly, linking it to cellular growth control.

In cancer research, LYAR is overexpressed in malignancies like neuroblastoma, prostate cancer, and hepatocellular carcinoma, where it promotes tumorigenesis by enhancing cell cycle progression and inhibiting apoptosis. Its oncogenic potential is partly attributed to interactions with MYC, a key regulator of ribosome biosynthesis. Additionally, LYAR plays a role in maintaining pluripotency in embryonic stem cells, modulating transcription factors like OCT4 and NANOG.

LYAR antibodies are widely used as tools to study its expression, localization, and function. They enable detection via techniques such as Western blotting, immunofluorescence, and immunohistochemistry, aiding research into its mechanistic roles in development and disease. Despite progress, LYAR's precise molecular pathways remain partially unresolved, spurring ongoing investigations into its therapeutic potential as a cancer target or regenerative medicine component.

       
关键字: LYAR抗体;LYAR;LYAR Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业,
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
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