FIBIN (Fin Bud Initiation Factor), also known as FAM204A, is a conserved protein encoded by the *FAM204A* gene, first identified in zebrafish for its role in regulating fin bud formation during embryonic development. Studies suggest it plays a critical role in tissue patterning and morphogenesis, particularly in appendage development. In mammals, FIBIN is expressed in various tissues, including the heart, limbs, and nervous system, and is implicated in modulating signaling pathways such as FGF (fibroblast growth factor) and BMP (bone morphogenetic protein), which are essential for cellular differentiation and organogenesis.
FIBIN antibodies are valuable tools for investigating its expression, localization, and function in developmental and pathological contexts. Researchers utilize these antibodies in techniques like immunohistochemistry, Western blotting, and immunofluorescence to study FIBIN's involvement in congenital anomalies, tissue regeneration, and diseases such as cancer. For example, altered FIBIN expression has been observed in certain tumors, suggesting potential roles in oncogenesis or metastasis. Despite its emerging significance, the precise molecular mechanisms of FIBIN remain under exploration. Current studies focus on its interactions with signaling molecules and its regulatory effects on gene expression networks. As a relatively novel target, FIBIN antibodies continue to support advances in developmental biology and disease research.