MOCOS抗体—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P10604(MOCOS Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

MOCOS (Molybdenum Cofactor Sulfurase) is a critical enzyme involved in the biosynthesis of the molybdenum cofactor (Moco), a prosthetic group essential for the function of enzymes like xanthine dehydrogenase (XDH) and aldehyde oxidase (AO). These enzymes play vital roles in purine metabolism, detoxification, and reactive oxygen species regulation. Mutations in the *MOCOS* gene are linked to hereditary xanthinuria type II, a rare metabolic disorder characterized by reduced urinary uric acid and elevated xanthine levels, increasing the risk of kidney stones.

MOCOS antibodies are specialized tools developed to detect and quantify MOCOS protein expression in research and clinical settings. They aid in studying MOCOS’s tissue distribution, regulatory mechanisms, and interactions within the Moco biosynthesis pathway. Such antibodies are crucial for investigating the molecular basis of MOCOS-related diseases, including potential links to neurological disorders and metabolic syndromes. Additionally, they support diagnostic applications, enabling the identification of MOCOS deficiencies through immunohistochemistry, Western blotting, or ELISA.

The development of MOCOS antibodies faces challenges due to the enzyme’s conserved domains and low expression levels in certain tissues. High-specificity antibodies are pivotal for distinguishing MOCOS from structurally similar proteins and validating its role in cellular models or animal studies. Ongoing research leverages these antibodies to explore therapeutic strategies, such as enzyme replacement or gene therapy, for MOCOS-associated conditions. Overall, MOCOS antibodies serve as indispensable reagents in advancing our understanding of molybdenum-dependent enzymatic pathways and their clinical implications.