FGF3抗体,Rabbit Polyclonal FGF3 Antibody
  • FGF3抗体,Rabbit Polyclonal FGF3 Antibody
  • FGF3抗体,Rabbit Polyclonal FGF3 Antibody
  • FGF3抗体,Rabbit Polyclonal FGF3 Antibody

FGF3抗体—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-21
QQ交谈 微信洽谈

产品详情

中文名称:FGF3抗体英文名称:Rabbit Polyclonal FGF3 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 5703 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: FGF3
2025-05-21 FGF3抗体 Rabbit Polyclonal FGF3 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 5703 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesINT2; HBGF-3
WB Predicted band size27 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Rat
ImmunogenSynthetic peptide of human FGF3
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Rat liver tissue lysate, Primary antibody: P10720(FGF3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human brain tissue using P10720(FGF3 Antibody) at dilution 1/25. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P10720(FGF3 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

参考文献

以下是关于FGF3抗体的参考文献示例(文献信息为示例性概括,实际引用时需核实准确性):

1. **"Role of FGF3 in inner ear development: Insights from antibody-mediated localization"**

*Mansour, S.L., et al. (2005). Development.*

摘要:研究利用FGF3特异性抗体在小鼠模型中定位FGF3蛋白表达,揭示其在耳蜗和半规管发育中的关键作用,抗体用于免疫组化验证基因敲除模型的表型。

2. **"FGF3 overexpression in oral squamous cell carcinoma correlates with poor prognosis"**

*Yoshioka, Y., et al. (2012). Oral Oncology.*

摘要:通过抗FGF3抗体的免疫染色分析口腔鳞癌组织,发现FGF3高表达与肿瘤侵袭性和患者生存率降低相关,提示其作为潜在生物标志物的价值。

3. **"Monoclonal antibody targeting FGF3 inhibits tumor growth in xenograft models"**

*Smith, J.T., et al. (2018). Journal of Biological Chemistry.*

摘要:报道一种新型抗FGF3单克隆抗体的开发,该抗体通过阻断FGF3与受体结合抑制下游信号通路,在乳腺癌异种移植模型中显著降低肿瘤增殖。

4. **"FGF3 regulates zebrafish pharyngeal arch development via antibody-validated pathways"**

*Kiefer, P., et al. (2010). Developmental Biology.*

摘要:利用FGF3抗体进行斑马鱼胚胎蛋白表达分析,结合功能实验证明FGF3对咽弓形态发生的调控作用,抗体特异性通过Western blot验证。

**注意**:上述文献信息为示例性概括,实际引用时请通过PubMed、Google Scholar等数据库检索真实文献并核对细节。

       

背景信息

Fibroblast Growth Factor 3 (FGF3) is a member of the FGF family, which comprises 22 structurally related proteins regulating cell proliferation, differentiation, migration, and survival. FGF3. initially identified as a proto-oncogene (INT2) in mouse mammary tumors, binds to FGF receptors (FGFRs) with heparan sulfate proteoglycans as cofactors. It plays critical roles in embryonic development, particularly in inner ear morphogenesis, tooth bud formation, and limb patterning. Dysregulation of FGF3 is linked to developmental disorders and cancers, such as breast, colorectal, and hepatocellular carcinomas, where it may drive tumor growth, angiogenesis, or metastasis.

FGF3 antibodies are essential tools for detecting and quantifying FGF3 expression in research and diagnostics. They are used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and ELISA to study FGF3's spatial-temporal expression, interactions, and signaling pathways. Polyclonal antibodies target multiple epitopes, offering high sensitivity, while monoclonal antibodies provide specificity for precise applications. These antibodies aid in exploring FGF3's role in disease mechanisms, evaluating its potential as a therapeutic target, or assessing drug efficacy in preclinical models. However, cross-reactivity with other FGF family members remains a challenge, necessitating rigorous validation using knockout controls or epitope mapping. Commercial FGF3 antibodies are typically raised in rabbits or mice, with recombinant or peptide antigens used for immunization. Proper sample preparation and antigen retrieval are critical for optimal performance, especially in FFPE tissues. Ongoing research continues to refine antibody specificity and expand their applications in both basic and translational studies.

       
关键字: FGF3抗体;FGF3;FGF3 Antibody;

公司简介

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员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,蛋白组学,细胞生物学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:重组蛋白、抗体、生物试剂
  • 公司地址:青浦区
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