The Dishevelled (DVL) family of proteins, including DVL2. are key regulators of Wnt signaling pathways, which play critical roles in embryonic development, tissue homeostasis, and disease. DVL2. one of three mammalian paralogs (DVL1-3), acts as a scaffold protein mediating both canonical (β-catenin-dependent) and non-canonical (e.g., planar cell polarity) Wnt signaling. It interacts with receptors like Frizzled to relay signals, influencing cell proliferation, differentiation, and polarity. Antibodies targeting DVL2 are essential tools for studying its expression, localization, and function in these pathways.
DVL2 antibodies are widely used in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to investigate Wnt-related mechanisms in developmental biology, cancer research (e.g., tumorigenesis, metastasis), and diseases like skeletal disorders or neurological conditions. Due to high homology among DVL isoforms, antibody specificity is a critical consideration; many commercial DVL2 antibodies are validated to minimize cross-reactivity with DVL1 or DVL3. Dysregulation of DVL2 is linked to cancers (e.g., colorectal, breast) and congenital anomalies, making these antibodies valuable for diagnostic or therapeutic research. Recent studies also explore DVL2's role in ciliopathies and regenerative medicine. Researchers often pair DVL2 antibodies with pathway inhibitors or activators to dissect its context-dependent roles in Wnt signaling crosstalk.