Growth arrest-specific 6 (GAS6) is a vitamin K-dependent protein that acts as a key ligand for the TAM receptor tyrosine kinase family (Tyro3. Axl, and Mer). It plays critical roles in regulating cellular processes such as survival, proliferation, migration, and immune modulation by activating downstream signaling pathways, including PI3K/AKT and MAPK. GAS6 is implicated in various physiological and pathological conditions, including inflammation, cancer progression, thrombosis, and tissue repair.
Antibodies targeting GAS6 are essential tools for studying its expression, function, and interaction with TAM receptors. They are widely used in research applications like Western blotting, immunohistochemistry, ELISA, and flow cytometry to quantify GAS6 levels in tissues or biological fluids. In therapeutic contexts, GAS6-neutralizing antibodies are being explored to inhibit oncogenic signaling, particularly in cancers with Axl receptor overexpression, where GAS6/AXL signaling promotes metastasis, drug resistance, and immune evasion. Additionally, these antibodies help elucidate GAS6's role in diseases like chronic kidney injury, fibrosis, and autoimmune disorders.
The development of high-specificity GAS6 antibodies has advanced mechanistic studies and preclinical evaluations, highlighting their potential as diagnostic biomarkers or targeted therapies in diseases driven by dysregulated TAM signaling.