STX17抗体—艾普蒂

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     Lane 1: SH-SY5Y lysate;  Lane 2: STX17 immunoprecipitated from SH-SY5Y lysate by P15842;  Lane 3: The same as Lane 2 but use IgG isotype control antibody ;Result: P15842 can immunoprecipitate STX17;    

  
  

The STX17 (syntaxin 17) antibody is a key tool for studying the molecular mechanisms of membrane trafficking and autophagy. STX17. a member of the SNARE protein family, plays a critical role in mediating membrane fusion events, particularly in autophagosome-lysosome fusion during autophagy. Discovered as a transmembrane protein localized to the endoplasmic reticulum (ER) and autophagosomes, STX17 interacts with partners like SNAP-29 and VAMP8 to facilitate autophagosome maturation. Its involvement in autophagy regulation has linked it to diseases such as cancer, neurodegeneration, and metabolic disorders.

Research using STX17 antibodies has revealed its dynamic recruitment to autophagosomal membranes during nutrient deprivation, where it coordinates lysosomal degradation of cellular components. These antibodies are widely employed in techniques like Western blotting, immunofluorescence, and immunoprecipitation to assess STX17 expression, subcellular localization, and protein interactions. Studies have also highlighted STX17’s role beyond autophagy, including secretory pathways and mitochondrial dynamics.

The antibody’s specificity often targets epitopes in STX17’s N-terminal or C-terminal domains, aiding in functional studies. Its development has been pivotal in validating knockout models and exploring therapeutic targets for autophagy-related disorders. Overall, STX17 antibodies remain essential for dissecting membrane trafficking mechanisms and their implications in health and disease.