PCDHAC1抗体,Rabbit Polyclonal PCDHAC1 Antibody
  • PCDHAC1抗体,Rabbit Polyclonal PCDHAC1 Antibody
  • PCDHAC1抗体,Rabbit Polyclonal PCDHAC1 Antibody
  • PCDHAC1抗体,Rabbit Polyclonal PCDHAC1 Antibody

PCDHAC1抗体;PCDHAC1 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-26
QQ交谈 微信洽谈

产品详情

中文名称:PCDHAC1抗体英文名称:Rabbit Polyclonal PCDHAC1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 6408 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: PCDHAC1
2025-05-26 PCDHAC1抗体 Rabbit Polyclonal PCDHAC1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 6408 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesPCDH-ALPHA-C1
WB Predicted band size104 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human PCDHAC1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: A549 cells, Primary antibody: P12028(PCDHAC1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P12028(PCDHAC1 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P12028(PCDHAC1 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于PCDHAC1抗体的3篇模拟参考文献(基于已有知识推测,非真实文献):

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1. **文献名称**:*PCDHAC1 expression in autism spectrum disorders: a novel synaptic biomarker*

**作者**:Smith J, et al.

**摘要**:本研究利用特异性PCDHAC1抗体检测了自闭症患者脑组织中的蛋白表达,发现PCDHAC1在皮层神经元突触中显著下调,提示其可能通过影响神经元连接参与疾病机制。

2. **文献名称**:*Development and validation of a high-affinity monoclonal antibody for PCDHAC1 detection*

**作者**:Li X, et al.

**摘要**:文章报道了一种新型PCDHAC1单克隆抗体的开发,通过免疫印迹和免疫组化验证其特异性,并应用于胶质瘤细胞系分析,证实PCDHAC1与肿瘤侵袭性相关。

3. **文献名称**:*PCDHAC1 regulates cortical interneuron migration via cell adhesion signaling*

**作者**:Garcia-Ruiz A, et al.

**摘要**:通过PCDHAC1抗体标记发现,该蛋白在小鼠胚胎皮层中间神经元迁移中起关键作用,其缺失导致细胞迁移障碍和异常神经网络形成。

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**说明**:以上文献为示例性质,实际研究需通过PubMed、Google Scholar等平台检索真实文献(可用关键词“PCDHAC1 antibody”或“Protocadherin AC1”)。

       

背景信息

The PCDHAC1 antibody is a research tool designed to detect protocadherin alpha cluster 1 (PCDHAC1), a member of the protocadherin alpha subfamily within the cadherin superfamily. Protocadherins are transmembrane proteins critical for cell-cell adhesion, neuronal development, and synaptic specificity in the central nervous system. The PCDHAC1 gene, located in the α-protocadherin cluster on human chromosome 5. encodes a calcium-dependent adhesion protein with six extracellular cadherin repeats, a transmembrane domain, and a variable cytoplasmic tail. These proteins are thought to contribute to neural circuit formation by promoting self-avoidance and neuronal diversity through stochastic gene expression.

The PCDHAC1 antibody is commonly used in neuroscience and developmental biology to study its expression pattern, localization, and function in neural tissues. Applications include immunohistochemistry (IHC), immunofluorescence (IF), and Western blotting (WB) in models ranging from human tissues to rodents. Dysregulation of PCDHAC1 has been implicated in neurodevelopmental disorders and certain cancers, making this antibody valuable for exploring disease mechanisms. Commercial PCDHAC1 antibodies are typically raised against specific epitopes, such as recombinant protein fragments, and require validation for specificity via knockout controls or siRNA knockdown. Researchers emphasize its role in understanding synaptic plasticity, axon guidance, and potential diagnostic or therapeutic targets.

       
关键字: PCDHAC1抗体;PCDHAC1;PCDHAC1 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
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