SSB抗体;SSB Antibody—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-4: K562 cells, 231 cells, Raji cells, hela cells, Primary antibody: P12243(SSB Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P12243(SSB Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P12243(SSB Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

SSB antibodies, also known as anti-La antibodies, are autoantibodies targeting the SSB (Sjögren syndrome type B) antigen, a 48-kDa RNA-binding protein involved in RNA polymerase III transcription termination and RNA processing. These antibodies are closely associated with autoimmune disorders, particularly Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE). SSB is often co-expressed with SSA/Ro antibodies, forming a serological hallmark of SS, where their presence correlates with glandular dysfunction (e.g., dry eyes/mouth) and extraglandular manifestations. In SLE, SSB antibodies are linked to photosensitivity, cutaneous vasculitis, and milder renal involvement.

The SSB antigen interacts with small RNA molecules, including Y RNAs and viral transcripts, suggesting roles in RNA quality control and antiviral responses. Autoimmunity against SSB may arise from molecular mimicry, apoptosis-induced exposure of intracellular antigens, or dysregulated tolerance mechanisms.

Clinically, SSB antibodies are detected via ELISA, immunoblot, or line immunoassay. While less common than SSA antibodies, their specificity for SS is higher when paired with SSA. Isolated SSB positivity is rare. These antibodies also hold prognostic value; in pregnant women with SSA/SSB antibodies, fetal exposure increases neonatal lupus risk, particularly congenital heart block. Research continues to explore their pathogenic role, including potential contributions to interferon pathway activation and epitope-specific immune responses. Their detection aids in disease classification and informs clinical monitoring strategies.