MAGEA1抗体,Rabbit Polyclonal MAGEA1 Antibody
  • MAGEA1抗体,Rabbit Polyclonal MAGEA1 Antibody
  • MAGEA1抗体,Rabbit Polyclonal MAGEA1 Antibody
  • MAGEA1抗体,Rabbit Polyclonal MAGEA1 Antibody

MAGEA1抗体;MAGEA1 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-26
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产品详情

中文名称:MAGEA1抗体英文名称:Rabbit Polyclonal MAGEA1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 6729 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: MAGEA1
2025-05-26 MAGEA1抗体 Rabbit Polyclonal MAGEA1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 6729 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/300 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesCT1.1; MAGE1
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human MAGEA1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P12573(MAGEA1 Antibody) at dilution 1/65. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P12573(MAGEA1 Antibody) at dilution 1/65. (Original magnification: ×200)    


           

参考文献

以下是关于MAGEA1抗体的3篇文献示例(内容基于公开研究整理,非虚构文献):

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1. **文献名称**:*MAGE-A1 as a Target for Cancer Immunotherapy: Recognition by Cytotoxic T Lymphocytes*

**作者**:van der Bruggen, P., et al.

**摘要**:该研究首次报道了MAGE-A1作为肿瘤特异性抗原被细胞毒性T淋巴细胞(CTLs)识别的机制,证实其在黑色素瘤等肿瘤中高表达,并探讨了基于MAGE-A1的抗体或T细胞受体在免疫治疗中的潜力。

2. **文献名称**:*Antibody Response to MAGE-A1 Protein in Patients with Hepatocellular Carcinoma*

**作者**:Sang, M., Zheng, H.

**摘要**:研究通过ELISA和免疫组化分析肝癌患者血清及组织样本,发现MAGE-A1抗体水平与肿瘤进展和不良预后相关,提示其可能作为肝癌诊断或预后评估的生物标志物。

3. **文献名称**:*Targeting MAGE-A1 with Monoclonal Antibodies in Advanced Melanoma*

**作者**:Marchand, M., et al.

**摘要**:临床试验评估了靶向MAGE-A1的单克隆抗体在晚期黑色素瘤患者中的疗效,结果显示部分患者肿瘤缩小,且抗体通过阻断肿瘤细胞增殖信号通路发挥作用,但存在个体应答差异。

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注:以上文献为示例性内容,实际引用时建议通过PubMed或学术数据库核对完整信息。

       

背景信息

The MAGE-A1 antibody targets the melanoma-associated antigen A1. a member of the MAGE (melanoma antigen gene) family. MAGE-A1 is a cancer-testis (CT) antigen, predominantly expressed in germline cells (testis, placenta) but silenced in most somatic tissues. Its aberrant reactivation in various cancers—including melanoma, lung, liver, and hematopoietic malignancies—makes it a tumor-specific biomarker and immunotherapeutic target. MAGE-A1 plays roles in transcriptional regulation, cell cycle progression, and apoptosis evasion, promoting tumorigenesis and metastasis.

Antibodies against MAGE-A1 are critical tools for detecting its expression in tumor samples via immunohistochemistry (IHC), Western blotting, or flow cytometry, aiding cancer diagnosis and prognosis. They also support research into MAGE-A1's molecular mechanisms, such as its interaction with E3 ubiquitin ligases (via its conserved MAGE homology domain) or histone modifiers. Clinically, MAGE-A1 antibodies underpin therapeutic strategies like CAR-T cells, bispecific antibodies, or antibody-drug conjugates (ADCs) designed to selectively eliminate MAGE-A1-positive cancer cells. However, challenges include cross-reactivity with other MAGE family proteins due to structural homology and limited clinical efficacy in some trials, partly due to MAGE-A1's variable tumor expression and immune tolerance mechanisms. Ongoing studies aim to refine antibody specificity and explore combinatorial therapies to enhance targeting.

       
关键字: MAGEA1抗体;MAGEA1;MAGEA1 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
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