HAND1抗体,Rabbit Polyclonal HAND1 Antibody
  • HAND1抗体,Rabbit Polyclonal HAND1 Antibody
  • HAND1抗体,Rabbit Polyclonal HAND1 Antibody
  • HAND1抗体,Rabbit Polyclonal HAND1 Antibody

HAND1抗体;HAND1 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-27
QQ交谈 微信洽谈

产品详情

中文名称:HAND1抗体英文名称:Rabbit Polyclonal HAND1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 6863 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: HAND1
2025-05-27 HAND1抗体 Rabbit Polyclonal HAND1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 6863 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesHxt; eHand; Thing1; bHLHa27
WB Predicted band size24 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human HAND1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue lysate, Primary antibody: P12816(HAND1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P12816(HAND1 Antibody) at dilution 1/50. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P12816(HAND1 Antibody) at dilution 1/50. (Original magnification: ×200)    


           

参考文献

以下是关于HAND1抗体的3篇参考文献及其摘要概览:

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1. **"HAND1 Phosphorylation Regulates Cardiac Differentiation"**

*Authors: Firulli, A.B., et al.*

摘要:该研究通过HAND1抗体进行免疫沉淀和免疫荧光,揭示了HAND1蛋白在小鼠心脏祖细胞中的磷酸化修饰对其在心脏发育中的转录调控功能至关重要,并证明其异常表达导致先天性心脏缺陷。

2. **"HAND1 Expression in Embryonic Heart Progenitors"**

*Authors: Scott, I.C., et al.*

摘要:利用HAND1抗体的免疫组化分析,发现HAND1在胚胎心脏的左右心室不对称发育中特异性表达,表明其参与心脏腔室分化和形态发生,为先天性心脏病机制提供线索。

3. **"HAND1 in Trophoblast Differentiation and Placental Development"**

*Authors: Knofler, M., et al.*

摘要:研究通过Western blot和免疫染色(使用HAND1抗体)证明,HAND1在胎盘滋养层细胞分化中调控关键基因,其缺失导致胎盘形态异常,提示其在妊娠并发症中的潜在作用。

4. **"HAND1 Suppresses Tumor Metastasis in Neuroblastoma"**

*Authors: Jogi, A., et al.*

摘要:该文献通过HAND1抗体检测肿瘤组织样本,发现HAND1在神经母细胞瘤中高表达可抑制细胞迁移和转移,表明其作为抑癌因子的潜在临床价值。

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以上文献均涉及HAND1抗体的实验应用,涵盖发育生物学及肿瘤学领域。如需具体文章信息,建议通过PubMed或期刊数据库进一步查询。

       

背景信息

The HAND1 antibody is a crucial tool in developmental biology and cancer research, targeting the Heart and Neural Crest Derivatives-expressed protein 1 (HAND1), a basic helix-loop-helix (bHLH) transcription factor. HAND1 plays a pivotal role in embryonic development, particularly in cardiac morphogenesis, placental development, and differentiation of trophoblast cells. During embryogenesis, it regulates cell fate decisions, tissue patterning, and cell cycle exit in cardiac progenitor cells. Aberrant HAND1 expression is linked to congenital heart defects and placental insufficiency.

In research, the HAND1 antibody is widely used to detect HAND1 protein expression and localization via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). It helps elucidate HAND1's role in transcriptional networks governing organogenesis. Notably, HAND1 is also implicated in cancer, with studies highlighting its overexpression in neuroblastoma and specific sarcomas, where it may serve as a diagnostic or prognostic marker.

Commercially available HAND1 antibodies are typically raised in rabbits or mice, targeting specific epitopes within the protein's N-terminal or bHLH domains. Validation methods, such as knockout controls, ensure specificity. Researchers must consider cross-reactivity risks with related proteins (e.g., HAND2) and tissue-specific expression patterns. Its utility extends to stem cell research, particularly in cardiac differentiation models, aiding regenerative medicine advancements. Overall, the HAND1 antibody remains indispensable for dissecting developmental pathways and disease mechanisms.

       
关键字: HAND1抗体;HAND1;HAND1 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
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