The USP24 antibody is a research tool designed to detect and study ubiquitin-specific protease 24 (USP24), a member of the deubiquitinating enzyme (DUB) family. USP24 plays a critical role in regulating protein degradation by removing ubiquitin chains from target proteins, thereby influencing cellular processes such as protein homeostasis, DNA repair, and stress response. Dysregulation of USP24 has been implicated in various diseases, including cancer, neurodegenerative disorders, and immune dysfunction, making it a subject of interest in biomedical research.
USP24 antibodies are typically developed in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments specific to USP24. These antibodies are validated for applications such as Western blotting, immunoprecipitation, immunofluorescence, and immunohistochemistry to assess USP24 expression levels, localization, and interactions in cells or tissues. Researchers rely on USP24 antibodies to explore its biological functions, such as its role in modulating the stability of key regulators (e.g., p53. PTEN) or its involvement in pathways like the ubiquitin-proteasome system and autophagy.
Due to potential cross-reactivity with other USP family members, rigorous validation (e.g., knockout cell controls) is essential to confirm antibody specificity. High-quality USP24 antibodies are critical for elucidating its mechanisms in disease contexts and evaluating its potential as a therapeutic target.