BACE2抗体,Rabbit Polyclonal BACE2 Antibody
  • BACE2抗体,Rabbit Polyclonal BACE2 Antibody
  • BACE2抗体,Rabbit Polyclonal BACE2 Antibody
  • BACE2抗体,Rabbit Polyclonal BACE2 Antibody

BACE2抗体;BACE2 Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-27
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产品详情

中文名称:BACE2抗体英文名称:Rabbit Polyclonal BACE2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 6951 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: BACE2
2025-05-27 BACE2抗体 Rabbit Polyclonal BACE2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 6951 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/10-1/50 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesASP1; BAE2; DRAP; AEPLC; ALP56; ASP21; CDA13; CEAP1
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human BACE2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human brain tissue using P12937(BACE2 Antibody) at dilution 1/25. (Original magnification: ×200)    


           

参考文献

以下是关于BACE2抗体的3篇示例参考文献(注:以下为假设性示例,实际文献需通过学术数据库验证):

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1. **文献名称**:*"Selective antibody-based targeting of BACE2 reveals its role in Alzheimer's disease pathology"*

**作者**:Sun, X. et al. (2020)

**摘要**:本研究开发了一种高特异性BACE2抗体,证实其在阿尔茨海默病模型中选择性抑制BACE2活性,减少β-淀粉样蛋白生成,且不影响同源蛋白BACE1的功能,提示BACE2可能成为治疗新靶点。

2. **文献名称**:*"Development of a monoclonal antibody distinguishing BACE2 from BACE1 in human brain tissues"*

**作者**:Vassar, R. et al. (2018)

**摘要**:通过杂交瘤技术制备了可区分BACE1和BACE2的单克隆抗体,验证其在人脑组织中的特异性,为研究两种蛋白酶在神经退行性疾病中的差异表达提供了关键工具。

3. **文献名称**:*"BACE2 antibody therapy ameliorates cognitive deficits in Down syndrome mouse models"*

**作者**:Sturdivant, S. et al. (2021)

**摘要**:利用抗BACE2抗体干预唐氏综合症小鼠模型,发现其能减少脑内异常淀粉样蛋白沉积并改善认知功能,表明BACE2在唐氏相关神经病理中具有重要作用。

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**提示**:实际文献需通过PubMed、Web of Science等平台以关键词“BACE2 antibody”检索,并筛选近年高被引研究。部分真实相关研究可能涉及BACE2在糖尿病或唐氏综合症中的功能探索。

       

背景信息

BACE2 (β-site amyloid precursor protein-cleaving enzyme 2) is a transmembrane aspartic protease closely related to BACE1. both involved in amyloid precursor protein (APP) processing. While BACE1 is a well-established therapeutic target for Alzheimer’s disease (AD) due to its role in generating neurotoxic β-amyloid peptides, BACE2 has dual, context-dependent functions. It can cleave APP at alternative sites, potentially reducing amyloid-β production, but also processes other substrates linked to metabolic disorders, including diabetes. BACE2 is highly expressed in pancreatic β-cells and regulates insulin secretion, with genetic variants associated with type 2 diabetes risk.

Antibodies targeting BACE2 are valuable tools for studying its expression, localization, and functional interplay with BACE1. They enable researchers to investigate tissue-specific roles, particularly in neurodegenerative and metabolic diseases. Therapeutic BACE2 antibodies are less advanced than BACE1 inhibitors but attract interest for their potential to modulate amyloid pathology without disrupting BACE1's physiological functions. Challenges include ensuring selectivity over BACE1 and optimizing blood-brain barrier penetration for AD applications. Recent studies also explore BACE2's role in cancer and Down syndrome, broadening its biomedical relevance. Commercial and custom BACE2 antibodies are widely used in immunoassays, Western blotting, and immunohistochemistry, supporting both basic research and drug development efforts.

       
关键字: BACE2抗体;BACE2;BACE2 Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

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