PIEZO2抗体;PIEZO2 Antibody—艾普蒂

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P13386(PIEZO2 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

The PIEZO2 antibody is a crucial tool for studying the PIEZO2 protein, a mechanosensitive ion channel central to sensing mechanical forces in various physiological processes. PIEZO2. encoded by the *PIEZO2* gene in humans, forms large, trimeric transmembrane channels that convert physical stimuli like touch, pressure, and stretch into electrochemical signals. It plays pivotal roles in light-touch perception, proprioception (body position awareness), and visceral mechanotransduction.

Antibodies targeting PIEZO2 are widely used in research to detect its expression, localization, and function. These antibodies, often developed in rabbits or mice, enable techniques such as Western blotting, immunohistochemistry, and immunofluorescence, helping map PIEZO2 distribution in tissues like sensory neurons, Merkel cells, and bladder urothelium. Their specificity is validated through knockout controls or peptide blocking assays.

Interest in PIEZO2 antibodies has surged due to the protein's link to human disorders. Mutations in *PIEZO2* are associated with distal arthrogryposis (congenital joint contractures), proprioceptive deficits, and impaired touch sensitivity. Research using these antibodies has advanced understanding of mechanobiology, neurodevelopment, and pathologies like chronic pain or bladder dysfunction. However, challenges remain, including optimizing antibody specificity given PIEZO2's structural complexity and homology with PIEZO1. Continued refinement of these reagents will further illuminate PIEZO2's roles in health and disease.