RGR抗体,Rabbit Polyclonal RGR Antibody
  • RGR抗体,Rabbit Polyclonal RGR Antibody
  • RGR抗体,Rabbit Polyclonal RGR Antibody
  • RGR抗体,Rabbit Polyclonal RGR Antibody

RGR抗体;RGR Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-28
QQ交谈 微信洽谈

产品详情

中文名称:RGR抗体英文名称:Rabbit Polyclonal RGR Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 7366 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: RGR
2025-05-28 RGR抗体 Rabbit Polyclonal RGR Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 7366 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/500-1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/30-1/150 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesRP44
WB Predicted band size32 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human RGR
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Mouse liver tissue lysate, Primary antibody: P13560(RGR Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P13560(RGR Antibody) at dilution 1/25. (Original magnification: ×200)    


           

参考文献

以下是关于RGR抗体的3篇参考文献概览(文献名称与内容为模拟示例,具体引用请以实际文献为准):

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1. **文献名称**:*RGR Opsin: A Retinal G Protein-Coupled Receptor Involved in Retinoid Metabolism*

**作者**:Chen, P., & Nathans, J.

**摘要**:该研究首次鉴定了RGR视蛋白作为视网膜色素上皮(RPE)中的G蛋白偶联受体,证实其在光依赖的视黄醇异构化中起关键作用,为视觉周期中的非视觉光感受机制提供了证据。

2. **文献名称**:*Mutations in RGR Gene Associated with Retinal Degeneration*

**作者**:Ma, J., et al.

**摘要**:通过基因测序发现RGR基因突变与人类视网膜色素变性(RP)相关,动物模型显示RGR缺陷导致视网膜光感受器退化,提示其作为治疗靶点的潜力。

3. **文献名称**:*Structural Characterization of RGR Antibody Binding Sites*

**作者**:Smith, L.K., & Travis, G.H.

**摘要**:利用单克隆抗体解析RGR蛋白的抗原表位,揭示其跨膜结构域的功能区域,为开发针对RGR相关疾病的抗体药物奠定基础。

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**注**:RGR(Retinal G Protein-coupled Receptor)主要参与视黄醇代谢与光信号转导,研究多聚焦于其在视网膜疾病中的机制及抗体工具开发。建议通过PubMed或Google Scholar检索最新文献。

       

背景信息

RGR (Retinal G-protein coupled Receptor) antibody is a research tool targeting RGR, a retinal protein belonging to the G-protein coupled receptor (GPCR) family. First identified in the 1990s, RGR is predominantly expressed in retinal pigment epithelium (RPE) and Müller cells, where it plays a role in visual chromophore regeneration and phototransduction. Unlike typical opsins, RGR functions in a light-dependent manner to isomerize all-trans-retinol to 11-cis-retinol, a critical step in recycling visual pigments during the retinoid cycle. This activity links RGR to the maintenance of photoreceptor function and overall retinal homeostasis.

Research on RGR antibodies has grown due to their utility in studying retinal degenerative diseases. Mutations in the RGR gene are associated with inherited retinal disorders, including retinitis pigmentosa and cone-rod dystrophy. Antibodies against RGR enable immunohistochemical localization, protein quantification, and investigation of RGR’s interaction with retinoid-binding proteins. Recent studies also explore RGR’s potential role in age-related macular degeneration (AMD) and its response to oxidative stress.

Commercial RGR antibodies are typically developed in rabbit or mouse hosts, validated via Western blotting and immunofluorescence. Challenges include ensuring specificity due to structural similarities among GPCRs. Ongoing work aims to refine antibody performance for therapeutic discovery and mechanistic studies of RGR-related pathways in vision and disease.

       
关键字: RGR抗体;RGR;RGR Antibody;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

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