SCAMP5抗体;SCAMP5 Antibody—艾普蒂 新品

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     Western blot analysis using SCAMP5 mouse mAb against  mouse brain lysate    

  
  

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     Lane 1: Mouse brain lysate ;  Lane 2: SCAMP5 immunoprecipitated from mouse brain lysate by P15206 ;  Lane 3: The same as Lane 2 but use IgG isotype control antibody ;Result: P15206 can immunoprecipitate SCAMP5;    

  
  

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     IHC-P analysis of cerebellum tissue by SCAMP5 antibody (P15206) IHC-P was performed using sections of the formalin-fixed paraffin-embedded cerebellum tissue;Result: Cytoplasm of cells in granular layer and in molecular layer are positively stained.    

  
  

The SCAMP5 (Secretory Carrier Membrane Protein 5) antibody is a tool used to study the SCAMP5 protein, a member of the SCAMP family involved in membrane trafficking and secretory pathways. SCAMPs are integral membrane proteins conserved across eukaryotes, playing roles in vesicle formation, fusion, and cargo sorting. SCAMP5. specifically, is enriched in neuronal and endocrine tissues, suggesting its importance in synaptic vesicle dynamics, neurosecretion, and neurotransmitter release. Research links SCAMP5 to neurological disorders; for example, altered SCAMP5 expression or mutations have been associated with autism spectrum disorders and schizophrenia, highlighting its potential role in synaptic plasticity and neural connectivity.

The SCAMP5 antibody is typically developed using immunogenic peptides or recombinant protein fragments to ensure specificity. It is widely utilized in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect SCAMP5 expression, localization, and interactions in cellular and tissue samples. Validation often includes knockout cell lines or siRNA knockdown to confirm target specificity. Recent studies also explore SCAMP5's involvement in cancer progression, particularly in regulating exosome secretion and tumor microenvironment communication. Commercial SCAMP5 antibodies are available from various suppliers, with applications spanning basic research to clinical investigations, aiding in elucidating its molecular mechanisms and therapeutic potential.