htrA1抗体;htrA1 Antibody—艾普蒂

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     Western blot analysis of htrA1 in MCF7 cell lysate.    

  
  

The HtrA1 (high-temperature requirement A1) antibody targets a secreted serine protease belonging to the HtrA family, which plays critical roles in extracellular matrix (ECM) remodeling, cell signaling, and stress response. HtrA1. encoded by the *HTRA1* gene, consists of an IGF-binding domain, a Kazal-type protease inhibitor domain, and a PDZ domain, enabling its interaction with substrates like TGF-β, fibronectin, and amyloid-β. Dysregulation of HtrA1 is linked to pathologies including age-related macular degeneration (AMD), osteoarthritis, cancer, and preeclampsia. In AMD, HtrA1 overexpression contributes to choroidal neovascularization by degrading ECM components, while in cancer, it exhibits dual roles—acting as a tumor suppressor or promoter depending on context.

HtrA1 antibodies are tools for detecting protein expression in tissues or fluids and modulating its enzymatic activity. Neutralizing antibodies inhibit HtrA1 proteolytic function, offering therapeutic potential in diseases driven by excessive ECM degradation. Conversely, diagnostic assays using HtrA1 antibodies help quantify protein levels in conditions like preeclampsia, where placental HtrA1 overexpression correlates with disease severity. Research also explores HtrA1 antibodies in biomarker discovery and understanding molecular pathways in neurodegeneration. Their development remains pivotal for both mechanistic studies and clinical applications targeting HtrA1-associated disorders.