ACBD3抗体;ACBD3 Antibody—艾普蒂 新品

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

ACBD3 (Acyl-CoA-binding domain-containing protein 3) is a ubiquitously expressed scaffolding protein involved in maintaining Golgi apparatus structure and regulating intracellular membrane trafficking. It belongs to the ACBD protein family, characterized by an N-terminal acyl-CoA-binding domain that interacts with lipids, and a C-terminal Golgi dynamics (GOLD) domain mediating protein-protein interactions. ACBD3 plays a critical role in organizing membrane contact sites between the Golgi and other organelles, such as mitochondria and peroxisomes. It also interacts with phosphoinositide kinases (e.g., PI4KIIIβ) to regulate phosphoinositide metabolism, influencing vesicle formation and signaling pathways.

ACBD3 antibodies are essential tools for studying its localization, expression, and molecular interactions. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate ACBD3's role in viral replication (e.g., picornaviruses exploit ACBD3 for replication organelle formation), lipid homeostasis, and diseases like cancer and neurodegenerative disorders. Polyclonal antibodies are often raised against recombinant ACBD3 fragments, ensuring specificity for human, mouse, or rat homologs. Recent studies highlight ACBD3's involvement in cell proliferation and apoptosis regulation, making its antibodies valuable for exploring therapeutic targets. Validation via knockout/knockdown controls is recommended due to potential cross-reactivity with homologous proteins.