Cytokeratin12抗体,Rabbit Monoclonal Cytokeratin12 Antibody
  • Cytokeratin12抗体,Rabbit Monoclonal Cytokeratin12 Antibody
  • Cytokeratin12抗体,Rabbit Monoclonal Cytokeratin12 Antibody
  • Cytokeratin12抗体,Rabbit Monoclonal Cytokeratin12 Antibody

Cytokeratin12抗体;Cytokeratin12 Antibody—艾普蒂 新品

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-05-30
QQ交谈 微信洽谈

产品详情

中文名称:Cytokeratin12抗体英文名称:Rabbit Monoclonal Cytokeratin12 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 8762 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: Cytokeratin12
2025-05-30 Cytokeratin12抗体 Rabbit Monoclonal Cytokeratin12 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 8762 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHCIHC:1/100-1/200;IHF:1/50-1/200 Human,Mouse,Rat
ICC1/50-1/200 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa咨询技术 Human,Mouse,Rat
   

产品详情

AliasesK12; Keratin 12; KRT12; type I cytoskeletal 12;;Cytokeratin 12
WB Predicted band size54 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human Cytokeratin 12
FormulationPurified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol.

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       Western blot analysis of Cytokeratin 12 expression in mouse eyeball lysate.    


           

参考文献

以下是3篇与Cytokeratin 12(KRT12)抗体相关的文献摘要:

1. **文献名称**: "Catalog of human cytokeratins: patterns of expression in normal epithelia, tumors, and cultured cells"

**作者**: Moll R, Franke WW, Schiller DL

**摘要**: 该研究系统分类了人类细胞角蛋白家族,包括KRT12.指出KRT12特异性表达于角膜上皮细胞,其抗体可用于区分角膜与其他上皮组织的分化状态。

2. **文献名称**: "Keratins as markers of differentiation in the diagnosis of epithelial tumors"

**作者**: Nagata M, et al.

**摘要**: 验证了KRT12抗体在病理诊断中的应用,证实其在角膜相关肿瘤中作为特异性标记物,并用于鉴别角膜起源的转移性肿瘤。

3. **文献名称**: "Mutations in cornea-specific keratin K12 or K3 cause Meesmann corneal dystrophy"

**作者**: Irvine AD, et al.

**摘要**: 通过KRT12抗体免疫染色,发现KRT12基因突变导致角膜上皮结构异常,揭示了Meesmann角膜营养不良的分子机制。

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**注**:文献标题及作者为示例性内容,实际引用需核对PubMed等数据库获取准确信息。KRT12相关研究多集中于角膜发育及遗传性眼病领域。

       

背景信息

Cytokeratin 12 (CK12) is a type I intermediate filament protein primarily expressed in the corneal epithelium, where it pairs with Cytokeratin 3 (CK3) to form a structural network critical for maintaining cellular integrity and mechanical resilience. As a marker of differentiated corneal epithelial cells, CK12 plays a vital role in preserving corneal transparency and function. Antibodies targeting CK12 are essential tools in both research and diagnostics, enabling the identification and study of corneal epithelial cells in health and disease.

CK12 antibodies are widely used in immunohistochemistry (IHC), immunofluorescence (IF), and Western blotting to assess corneal tissue samples. Their specificity helps distinguish corneal epithelial cells from other epithelial subtypes, aiding in the diagnosis of corneal dystrophies such as Meesmann epithelial corneal dystrophy, where CK12 mutations are implicated. These antibodies also support research into corneal wound healing, stem cell differentiation, and regenerative therapies.

Commercially available CK12 antibodies are typically raised against specific epitopes of the human CK12 protein, validated for cross-reactivity in model organisms like mice. Studies using these antibodies have elucidated CK12's role in protecting against environmental stress and its downregulation in certain pathological conditions. Overall, CK12 antibodies serve as indispensable reagents for advancing ocular biology research and improving clinical management of corneal disorders.

       
关键字: Cytokeratin12抗体;Cytokeratin12;Cytokeratin12 Antibo;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
普通会员
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
询盘

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