FDX1/ADX抗体;FDX1/ADX Antibody—艾普蒂 新品

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     Western blot analysis of FDX1 / ADX expression in A549 cell lysate.    

  
  

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     Immunofluorescent analysis using the Antibody at 1:50 dilution.    

  
  

FDX1 (ferredoxin 1), also known as ADX (adrenodoxin), is a small iron-sulfur protein critical for electron transfer in mitochondrial steroidogenesis and redox metabolism. It functions as an essential electron shuttle between NADPH-adrenodoxin reductase and cytochrome P450 enzymes (e.g., CYP11A1. CYP11B1), enabling biosynthesis of steroid hormones, bile acids, and vitamin D. FDX1/ADX is highly expressed in steroidogenic tissues like the adrenal cortex, ovaries, and testes.

Antibodies targeting FDX1/ADX are widely used to study its expression, localization, and interactions in metabolic pathways. They are vital tools for investigating disorders linked to steroid hormone imbalances, such as congenital adrenal hyperplasia, and for exploring FDX1's emerging roles in cancer and neurodegenerative diseases. Recent studies highlight FDX1's involvement in copper-dependent cell death (cuproptosis) and its interaction with the anticancer agent elesclomol, positioning it as a potential therapeutic target.

In research, FDX1/ADX antibodies are applied in techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation to dissect its regulatory mechanisms. These antibodies also aid in characterizing microbial homologs in pathogens, expanding their utility in infectious disease studies. Their specificity ensures accurate detection of FDX1's redox-active conformations, supporting both basic science and clinical investigations into mitochondrial dysfunction and metabolic disorders.