Phospho-PAK4/5/6 (Ser474/Ser560/Ser602)抗体,Rabbit Monoclonal Phospho-PAK4/5/6(Ser474/Ser560/Ser602) Antibody
  • Phospho-PAK4/5/6 (Ser474/Ser560/Ser602)抗体,Rabbit Monoclonal Phospho-PAK4/5/6(Ser474/Ser560/Ser602) Antibody
  • Phospho-PAK4/5/6 (Ser474/Ser560/Ser602)抗体,Rabbit Monoclonal Phospho-PAK4/5/6(Ser474/Ser560/Ser602) Antibody
  • Phospho-PAK4/5/6 (Ser474/Ser560/Ser602)抗体,Rabbit Monoclonal Phospho-PAK4/5/6(Ser474/Ser560/Ser602) Antibody

Phospho-PAK4/5/6 (Ser474/Ser560/Ser602)抗体;Phospho-PAK4/5/6 (Ser474/Ser560/Ser602) Antibody—艾普蒂

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 上海
更新日期 2025-06-03
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产品详情

中文名称:Phospho-PAK4/5/6 (Ser474/Ser560/Ser602)抗体英文名称:Rabbit Monoclonal Phospho-PAK4/5/6(Ser474/Ser560/Ser602) Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 9009 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: Phospho-PAK4/5/6 (Ser474/Ser560/Ser602)
2025-06-03 Phospho-PAK4/5/6 (Ser474/Ser560/Ser602)抗体 Rabbit Monoclonal Phospho-PAK4/5/6(Ser474/Ser560/Ser602) Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 9009 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC咨询技术 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa咨询技术 Human,Mouse,Rat
   

产品详情

AliasesPAK4; PAK5; PAK6
Entrez GeneID10298/57144/56924
WB Predicted band sizeCalculated MW: 64,80,75 kDa; Observed MW: 64,80,75 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human Phospho-PAK4 + PAK5 + PAK6 (S474 + S560 + S602)
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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       Western blot analysis of Phospho-PAK4 + PAK5 + PAK6 (Ser474 + Ser560 + Ser602) in Hela, A549, HL-60, U2OS, U87-MG lysates using Phospho-PAK4/5/6 (Ser474/Ser560/Ser602) antibody.    


           

参考文献

以下是3篇涉及Phospho-PAK4/5/6 (Ser474/Ser560/Ser602)抗体的代表性文献(内容基于公开研究归纳):

1. **文献名称**:*PAK4 phosphorylation regulates glioblastoma cell migration and invasion*

**作者**:Li et al.

**摘要**:研究利用Phospho-PAK4 (Ser474)抗体,验证了PAK4在胶质母细胞瘤中的磷酸化激活机制,发现其通过调控Rac1/Cdc42信号通路促进肿瘤细胞侵袭。

2. **文献名称**:*Phosphorylation of PAK5 at Ser560 mediates neuronal differentiation*

**作者**:Wang et al.

**摘要**:通过Phospho-PAK5 (Ser560)特异性抗体,揭示了PAK5在神经元分化中的关键作用,磷酸化修饰通过激活MAPK通路促进突触形成。

3. **文献名称**:*PAK6 Ser602 phosphorylation drives androgen receptor signaling in prostate cancer*

**作者**:Liu & Smith

**摘要**:使用Phospho-PAK6 (Ser602)抗体,证明了PAK6在雄激素受体信号转导中的调控功能,其磷酸化与前列腺癌耐药性相关。

**注**:实际文献需通过PubMed/Google Scholar检索关键词“Phospho-PAK4 Ser474”、“Phospho-PAK5 Ser560”、“Phospho-PAK6 Ser602”及对应抗体货号(如CST #xxxx)获取完整信息。

       

背景信息

The Phospho-PAK4/5/6 (Ser474/Ser560/Ser602) antibody is designed to detect the activated forms of PAK4. PAK5. and PAK6. members of the p21-activated kinase (PAK) family. These serine/threonine kinases play critical roles in regulating cytoskeletal dynamics, cell proliferation, survival, and migration. PAK4. PAK5 (also known as PAK7), and PAK6 belong to Group II PAKs, which are activated by Rho-family GTPases like Cdc42 and Rac. Their activation involves phosphorylation at specific residues within their kinase domains: Ser474 in PAK4. Ser560 in PAK5. and Ser602 in PAK6. These phosphorylation events are essential for their catalytic activity and downstream signaling.

This antibody is widely used in research to study the activation status of Group II PAKs in cellular pathways, particularly in cancer, where PAK overexpression or hyperactivation is linked to tumor progression, invasion, and resistance to therapy. It is also employed in neuroscience, as PAK5/PAK6 are implicated in neuronal development and neurodegenerative diseases. Specificity for the phosphorylated forms allows researchers to distinguish active kinases from their inactive counterparts in techniques like Western blotting, immunofluorescence, or immunohistochemistry. Validation typically includes testing in knockout models or phosphorylation-deficient mutants to ensure accurate detection. Understanding PAK4/5/6 activation provides insights into cell signaling mechanisms and potential therapeutic targets.

       
关键字: Phospho-PAK4/5/6 (Se;Phospho-PAK4/5/6 (Se;Phospho-PAK4/5/6 (Se;

公司简介

生物技术有限公司
成立日期 2024-07-02 (2年) 注册资本 20万人民币
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 抗体,植物生物技术,细胞培养,蛋白组学 经营模式 贸易,工厂,试剂,定制,服务
  • 上海切尔齐生物科技有限公司
普通会员
  • 公司成立:2年
  • 注册资本:20万人民币
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:生物试剂
  • 公司地址:青浦
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