Phospho-HDAC6 (Ser22)抗体;Phospho-HDAC6 (Ser22) Antibody—艾普蒂 新品

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     Western blot analysis of Phospho-HDAC6 (Ser22) in 3T3 lysates using Phospho-HDAC6 (Ser22) antibody.    

  
  

Phospho-HDAC6 (Ser22) antibody is a specialized tool used to detect the phosphorylation status of histone deacetylase 6 (HDAC6) at serine residue 22. HDAC6. a class IIb deacetylase, is primarily localized in the cytoplasm and regulates diverse cellular processes by deacetylating non-histone substrates such as α-tubulin, HSP90. and cortactin. Its activity is modulated by post-translational modifications, including phosphorylation, which can influence enzymatic activity, substrate binding, or protein interactions. Phosphorylation at Ser22 has been implicated in regulating HDAC6 function in response to cellular stress, signaling pathways, or disease states, though the exact mechanisms remain under investigation.

This phospho-specific antibody enables researchers to study HDAC6 activation or inactivation in contexts such as cancer progression, neurodegenerative disorders, and immune responses. For example, HDAC6 phosphorylation may correlate with altered microtubule dynamics, protein aggregation clearance, or stress granule formation. The antibody is commonly used in techniques like Western blotting, immunofluorescence, or immunoprecipitation to assess phosphorylation-dependent HDAC6 behavior in cell lysates or tissues. Proper controls, such as dephosphorylation treatments or kinase/phosphatase inhibitors, are critical to validate specificity. Understanding Ser22 phosphorylation could reveal novel therapeutic targets, as HDAC6 dysregulation is linked to pathologies including chemotherapy resistance and tauopathy in Alzheimer’s disease.