Human CD79B Protein, His Tag (MALS verified)
分子别名(Synonym)
CD79b,B29,IGB,Ig-beta
表达区间及表达系统(Source)
Human CD79B, His Tag (CDB-H52H3) is expressed from human 293 cells (HEK293). It contains AA Ala 29 - Asp 159 (Accession # P40259-1).
Predicted N-terminus: Ala 29
蛋白结构(Molecular Characterization)

This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 17.1 kDa. The protein migrates as 30-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
内毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method / rFC method.
纯度(Purity)
>90% as determined by SDS-PAGE.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, 0.2 M Arginine, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.


背景介绍
B细胞抗原受体复合物相关蛋白β链(CD79b,亦称B细胞特异性糖蛋白B29、Ig-β、免疫球蛋白相关B29蛋白、B29及IGB)是一种I型单次跨膜蛋白,其结构包含一个免疫球蛋白样V型结构域和一个免疫受体酪氨酸激活基序(ITAM)结构域。CD79b需与CD79A协同作用,启动B细胞抗原受体复合物(BCR)激活的信号转导级联反应。该蛋白可通过招募磷酸化CD79A的激酶或结合CD79A并保护其免于去磷酸化的蛋白,增强CD79A的磷酸化水平。CD79b缺陷会导致6型无丙种球蛋白血症(AGM6),这是一种以血清抗体水平极低或缺如、循环B细胞数量显著减少或缺失为特征的原发性免疫缺陷病,病因在于B细胞发育早期受阻。
关键字: CD79B;CD79B蛋白;CD79B重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。